Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
cylindrospermopsin [CPD:C19999];
succinate [CPD:C00042];
CO2 [CPD:C00011];
7-epi-cylindrospermopsin [CPD:C22222]
Comment
Requires iron(II). The enzyme, found in some cyanobacterial species, catalyses the last step in the biosynthesis of the toxins cylindrospermopsin and 7-epi-cylindrospermopsin. The ratio of the two products differs among different strains.
Mazmouz R, Chapuis-Hugon F, Pichon V, Mejean A, Ploux O
Title
The last step of the biosynthesis of the cyanotoxins cylindrospermopsin and 7-epi-cylindrospermopsin is catalysed by CyrI, a 2-Oxoglutarate-dependent iron oxygenase.
Mazmouz R, Essadik I, Hamdane D, Mejean A, Ploux O
Title
Characterization of CyrI, the hydroxylase involved in the last step of cylindrospermopsin biosynthesis: Binding studies, site-directed mutagenesis and stereoselectivity.
