Entry
Name
5-dehydro-6-demethoxyfumagillol dioxygenase;
fmaF (gene name);
Fma-C6H
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
5-dehydro-6-demethoxyfumagillol,2-oxoglutarate:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
5-dehydro-6-demethoxyfumagillol + 2-oxoglutarate + O2 = 5-dehydro-6-demethoxy-6-hydroxyfumagillol + succinate + CO2 [RN:
R13122 ]
Reaction(KEGG)
Substrate
5-dehydro-6-demethoxyfumagillol [CPD:
C22629 ];
2-oxoglutarate [CPD:
C00026 ];
O2 [CPD:
C00007 ]
Product
5-dehydro-6-demethoxy-6-hydroxyfumagillol [CPD:
C22631 ];
succinate [CPD:
C00042 ];
CO2 [CPD:
C00011 ]
Comment
Requires iron(II). The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin.
History
EC 1.14.11.82 created 2022
Pathway
ec00998 Biosynthesis of various antibiotics
ec01110 Biosynthesis of secondary metabolites
Orthology
K22570 5-dehydro-6-demethoxyfumagillol dioxygenase
Genes
Taxonomy
Reference
Authors
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
Title
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
Journal
Sequence
Other DBs
LinkDB
All DBs