Entry
Name
taxoid 14beta-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
10beta-hydroxytaxa-4(20),11-dien-5alpha-yl-acetate,NADPH:oxygen 14-oxidoreductase
Reaction(IUBMB)
10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O [RN:
R09867 ]
Reaction(KEGG)
Substrate
Product
10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate [CPD:
C20151 ];
NADP+ [CPD:
C00006 ];
H2O [CPD:
C00001 ]
Comment
Requires cytochrome P450. From the yew Taxus cuspidata. Also acts on taxa-4(20),11-dien-5alpha-yl acetate.
History
EC 1.14.13.146 created 2012
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K20512 taxoid 14beta-hydroxylase
Reference
Authors
Jennewein S, Rithner CD, Williams RM, Croteau R
Title
Taxoid metabolism: Taxoid 14beta-hydroxylase is a cytochrome P450-dependent monooxygenase.
Journal
Sequence
Other DBs
LinkDB
All DBs