KEGG ENZYME: 1.14.15.27

ENZYME: 1.14.15.27

Entry

EC 1.14.15.27               Enzyme

Name

beta-dihydromenaquinone-9 omega-hydroxylase;
cyp128 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

beta-dihydromenaquinone-9,reduced ferredoxin:oxygen oxidoreductase (omega-hydroxylating)

Reaction(IUBMB)

beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 = omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O [RN:R12073]

Reaction(KEGG)

R12073

Substrate

beta-dihydromenaquinone-9 [CPD:C21527];
reduced ferredoxin [iron-sulfur] cluster [CPD:C00138];
O2 [CPD:C00007]

Product

omega-hydroxy-beta-dihydromenaquinone-9 [CPD:C21885];
oxidized ferredoxin [iron-sulfur] cluster [CPD:C00139];
H2O [CPD:C00001]

Comment

The bacterial cytochrome P-450 enzyme is involved in the biosynthesis of omega-sulfo-beta-dihydromenaquinone-9 by members of the Mycobacterium tuberculosis complex.

History

EC 1.14.15.27 created 2018

Orthology

K21199

beta-dihydromenaquinone-9 omega-hydroxylase

Genes

MTU:	Rv2268c(cyp128)

MTV:	RVBD_2268c

MTC:

MT2330

MRA:	MRA_2288(cyp128)

MTF:	TBFG_12295

MTB:	TBMG_01714

MTK:	TBSG_01724

MTZ:	TBXG_001696

MTI:	MRGA423_14110

MTE:	CCDC5079_2104

MTUR:

CFBS_2401(cyp128)

MTL:	CCDC5180_2076

MTO:	MTCTRI2_2303(cyp128)

MTD:	UDA_2268c(cyp128)

MTN:	ERDMAN_2492

MTJ:	J112_12175

MTUB:

MT7199_2299(cyp128)

MTUC:

J113_15810

MTUE:

J114_12165

MTX:	M943_11740

MTUH:

I917_16005 I917_16010

MTUL:

TBHG_02218

MTUT:

HKBT1_2392(cyp128)

MTUU:

HKBT2_2394(cyp128)

MTQ:	HKBS1_2398(cyp128)

MBO:	BQ2027_MB2291C(cyp128)

MBB:	BCG_2285c(cyp128)

MBT:	JTY_2279(cyp128)

MBM:	BCGMEX_2273c(cyp128)

MBK:	K60_023530

MBX:

BCGT_2091

MAF:	MAF_22780(cyp128)

MMIC:

RN08_2516

MCE:	MCAN_05821 MCAN_22921(cyp128)

MCQ:	BN44_50214(cyp)

MCV:	BN43_31510(cyp)

MCX:	BN42_20320(cyp) BN42_40190(cyp)

MCZ:	BN45_10648(cyp)

MORY:

MO_002377

MKN:	MKAN_03520

MSHG:

MSG_00557(cyp128)

MPAG:

C0J29_29690

MNM:	MNVM_38540(cyp128)

MCOO:

MCOO_18140(cyp128)

MGAU:

MGALJ_29100

MLJ:	MLAC_22890(cyp128)

MSHJ:

MSHI_09960(cyp128)

MMAM:

K3U93_19825 K3U93_21455

MPAA:

MKK62_06670

MWU:	PT015_10735

MMOR:

MMOR_46050(cyp128_2)

MGAD:

MGAD_53320(cyp128_2)

MANY:

MANY_06260(cyp128_1) MANY_39810(cyp128_2)

MPAE:

K0O64_08735

MCRO:

MI149_10205

MCHE:

BB28_22795

MIZ:	BAB75_25240

MSAO:

MYCSP_20800

MSAL:

DSM43276_04313

MHER:

K3U94_12375

MVM:	MJO54_12320

CATI:

CS0771_54690

» show all

Reference

1 [PMID:18928249]

Authors

Holsclaw CM, Sogi KM, Gilmore SA, Schelle MW, Leavell MD, Bertozzi CR, Leary JA

Title

Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis.

Journal

ACS Chem Biol 3:619-24 (2008)
DOI:10.1021/cb800145r

Reference

2 [PMID:27933784]

Authors

Sogi KM, Holsclaw CM, Fragiadakis GK, Nomura DK, Leary JA, Bertozzi CR

Title

Biosynthesis and Regulation of Sulfomenaquinone, a Metabolite Associated with Virulence in Mycobacterium tuberculosis.

Journal

ACS Infect Dis 2:800-806 (2016)
DOI:10.1021/acsinfecdis.6b00106

Sequence

[mtu:Rv2268c]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.15.27

IUBMB Enzyme Nomenclature:

1.14.15.27

ExPASy - ENZYME nomenclature database:

1.14.15.27

BRENDA, the Enzyme Database:

1.14.15.27

LinkDB

DBGET integrated database retrieval system