KEGG   ENZYME: 1.14.20.8
Entry
EC 1.14.20.8                Enzyme                                 
Name
(-)-deoxypodophyllotoxin synthase;
2-ODD (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and the other dehydrogenated
Sysname
(-)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming)
Reaction(IUBMB)
(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O [RN:R11210]
Reaction(KEGG)
R11210
Substrate
(-)-yatein [CPD:C10557];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007]
Product
(-)-deoxypodophyllotoxin [CPD:C10556];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum (mayapple), is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.
History
EC 1.14.20.8 created 2016 as EC 1.14.11.50, transferred 2018 to EC 1.14.20.8
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21202  (-)-deoxypodophyllotoxin synthase
Reference
1  [PMID:26359402]
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.20.8
IUBMB Enzyme Nomenclature: 1.14.20.8
ExPASy - ENZYME nomenclature database: 1.14.20.8
BRENDA, the Enzyme Database: 1.14.20.8
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