Entry
Name
androst-4-ene-3,17-dione monooxygenase;
androstene-3,17-dione hydroxylase;
androst-4-ene-3,17-dione 17-oxidoreductase;
androst-4-ene-3,17-dione hydroxylase;
androstenedione monooxygenase;
4-androstene-3,17-dione monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)
Reaction(IUBMB)
androstenedione + reduced acceptor + O2 = testololactone + acceptor + H2O [RN:
R01833 ]
Reaction(KEGG)
Substrate
Product
Comment
Has a wide specificity. A single enzyme from the ascomycete Neonectria radicicola (EC
1.14.13.54 , ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC
1.14.99.4 , progesterone monooxygenase.
History
EC 1.14.99.12 created 1972, modified 1999
Pathway
ec00140 Steroid hormone biosynthesis
Reference
Authors
PRAIRIE RL, TALALAY P.
Title
Enzymatic formation of testololactone.
Journal
Other DBs
LinkDB
All DBs