KEGG   ENZYME: 1.17.4.4
Entry
EC 1.17.4.4                 Enzyme                                 
Name
vitamin-K-epoxide reductase (warfarin-sensitive);
VKORC1 (gene name);
VKORC1L1 (gene name)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With a disulfide as acceptor
Sysname
phylloquinone:disulfide oxidoreductase
Reaction(IUBMB)
(1) phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues [RN:R03511];
(2) phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues
Reaction(KEGG)
R03511;
(other) R03645 R09992
Substrate
phylloquinone [CPD:C02059];
protein with a disulfide bond;
H2O [CPD:C00001];
phylloquinol [CPD:C03313]
Product
2,3-epoxyphylloquinone [CPD:C05849];
protein with reduced L-cysteine residues;
phylloquinone [CPD:C02059]
Comment
The enzyme catalyses the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, peptidyl-glutamate 4-carboxylase, back to its phylloquinol active form. The enzyme forms a tight complex with EC 5.3.4.1, protein disulfide-isomerase, which transfers the required electrons from newly-synthesized proteins by catalysing the formation of disulfide bridges. The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2). Inhibited strongly by (S)-warfarin and ferulenol.
History
EC 1.17.4.4 created 1989 as EC 1.1.4.1, transferred 2014 to EC 1.17.4.4, modified 2018
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05357  vitamin-K-epoxide reductase (warfarin-sensitive)
Genes
HSA: 154807(VKORC1L1) 79001(VKORC1)
PTR: 100610370(VKORC1) 472396(VKORC1L1)
PPS: 100979578(VKORC1L1) 103784246(VKORC1)
GGO: 101127117(VKORC1) 101145443(VKORC1L1)
PON: 100434981(VKORC1) 100458063(VKORC1L1) 112134373
NLE: 100591850(VKORC1) 100601157 100601262(VKORC1L1)
HMH: 116471184(VKORC1) 116811828(VKORC1L1)
MCC: 114676888 697591(VKORC1L1) 714412(VKORC1)
MCF: 101926368(VKORC1) 102131386 102143754(VKORC1L1)
MTHB: 126944258 126946887 126950311
MNI: 105482950(VKORC1)
CSAB: 103231221(VKORC1) 103246568(VKORC1L1) 103246572 103246927
CATY: 105574592 105581545 105593305(VKORC1L1) 105599496(VKORC1)
PANU: 101007749(VKORC1L1) 101025627(VKORC1)
TGE: 112614204(VKORC1) 112620261 112620583
MLEU: 105541466(VKORC1) 105548721 105548733 105548736
RRO: 104661567(VKORC1) 104678399 104678964(VKORC1L1)
RBB: 108529701(VKORC1)
TFN: 117072927(VKORC1L1) 117072933 117073356 117087689(VKORC1)
PTEH: 111525670(VKORC1) 111530454 111535958 113219667
CANG: 105505703(VKORC1) 105518960(VKORC1L1)
CJC: 100386573(VKORC1) 100388998(VKORC1L1)
SBQ: 101041739(VKORC1) 101051522(VKORC1L1)
CIMI: 108290018(VKORC1L1) 108293888(VKORC1) 108296609
CSYR: 103264390(VKORC1)
MMUR: 105871014(VKORC1L1) 105871049(VKORC1)
LCAT: 123632662(VKORC1L1) 123632698(VKORC1)
PCOQ: 105807073(VKORC1L1) 105823161(VKORC1)
OGA: 100947581(VKORC1) 100952951(VKORC1L1)
MMU: 27973(Vkorc1) 69568(Vkorc1l1)
MCAL: 110295344(Vkorc1l1) 110298355(Vkorc1)
MPAH: 110332422(Vkorc1)
RNO: 309004(Vkorc1) 399684(Vkorc1l1)
MCOC: 116068488(Vkorc1l1) 116100916(Vkorc1)
ANU: 117698190(Vkorc1l1) 117702411 117714244(Vkorc1)
MUN: 110560966(Vkorc1l1) 110564537(Vkorc1)
CGE: 100755703(Vkorc1) 100757934(Vkorc1l1)
MAUA: 101836225(Vkorc1l1) 101840628(Vkorc1)
PROB: 127228408(Vkorc1) 127236909(Vkorc1l1)
PLEU: 114693670(Vkorc1l1) 114704396(Vkorc1)
MORG: 121446041(Vkorc1l1) 121457867(Vkorc1)
MFOT: 126504211 126515876
AAMP: 119820462(Vkorc1) 119824745(Vkorc1l1)
NGI: 103726327(Vkorc1) 103738949(Vkorc1l1)
HGL: 101708956(Vkorc1l1) 101712053 101712530(Vkorc1)
CPOC: 100717597(Vkorc1) 100720684(Vkorc1l1)
CCAN: 109682419(Vkorc1)
DORD: 105982096(Vkorc1)
DSP: 122096196(Vkorc1) 122114838(Vkorc1l1)
PLOP: 125338758(Vkorc1l1) 125341148(Vkorc1)
NCAR: 124969992 124970058
MMMA: 107146575(Vkorc1l1) 107146973(Vkorc1)
OCU: 100348035 100352876
OPI: 101519736(VKORC1L1) 101520237 101524326
TUP: 102473374(VKORC1L1) 102489609(VKORC1)
GVR: 103600701(VKORC1L1) 103610025(VKORC1)
CFA: 479775(VKORC1) 606915(VKORC1L1)
CLUD: 112640131(VKORC1) 112646081(VKORC1L1)
VVP: 112929263(VKORC1) 112934105(VKORC1L1)
VLG: 121486425(VKORC1L1) 121487294(VKORC1)
NPO: 129519250(VKORC1) 129519602(VKORC1L1)
AML: 100473818(VKORC1L1) 100476494(VKORC1)
UMR: 103657883(VKORC1) 103670242(VKORC1L1)
UAH: 113267716(VKORC1) 113267747(VKORC1L1)
UAR: 123784675(VKORC1) 123784703(VKORC1L1)
ELK: 111146341 111162267
LLV: 125090151 125090200
MPUF: 101677403(VKORC1) 101685820(VKORC1L1)
MNP: 132026663(VKORC1L1) 132026687(VKORC1)
MLK: 131819093(VKORC1) 131819663(VKORC1L1)
NVS: 122895760(VKORC1) 122895982(VKORC1L1)
ORO: 101365518(VKORC1L1) 101379206(VKORC1)
EJU: 114214375(VKORC1L1) 114214419(VKORC1)
ZCA: 113932409(VKORC1) 113933167(VKORC1L1)
MLX: 117999538(VKORC1L1) 117999567(VKORC1)
NSU: 110589734(VKORC1L1) 110589940(VKORC1)
LWW: 102726064(VKORC1) 102742852(VKORC1L1)
FCA: 101085010(VKORC1L1) 101089669(VKORC1)
PYU: 121017459(VKORC1L1) 121022198(VKORC1)
PCOO: 112857064(VKORC1) 112859869(VKORC1L1)
PBG: 122471386(VKORC1L1) 122471420(VKORC1)
PVIV: 125153945(VKORC1) 125154529(VKORC1L1)
LRUF: 124517843 124519158
PTG: 102964464(VKORC1) 102969550(VKORC1L1)
PPAD: 109250658(VKORC1L1) 109259045(VKORC1) 109261808
PUC: 125928111 125928154
AJU: 106972842 106979129
HHV: 120235669(VKORC1L1) 120242261(VKORC1)
BTA: 445422(VKORC1) 506318(VKORC1L1)
BOM: 102273264(VKORC1) 102276117(VKORC1L1)
BIU: 109578500(VKORC1)
BBUB: 102399074(VKORC1L1) 102404250(VKORC1)
BBIS: 104986679(VKORC1) 104986777(VKORC1L1)
CHX: 102171296(VKORC1) 102174084(VKORC1L1)
OAS: 101108541(VKORC1L1) 105604738(VKORC1)
BTAX: 128043381(VKORC1) 128069046(VKORC1L1)
ODA: 120860595 120860596 120877656(VKORC1) 120877982(VKORC1L1)
CCAD: 122432710(VKORC1) 122432970(VKORC1L1)
MBEZ: 129545559(VKORC1) 129545586(VKORC1L1)
SSC: 100518062(VKORC1L1) 100522924(VKORC1)
CFR: 102506472(VKORC1L1) 102515335(VKORC1)
CBAI: 105082780(VKORC1) 105082868(VKORC1L1)
CDK: 105089738(VKORC1L1) 105102715(VKORC1)
VPC: 102530603(VKORC1) 102542192(VKORC1L1)
BACU: 103001696(VKORC1) 103011563(VKORC1L1)
BMUS: 118880606(VKORC1) 118880642(VKORC1L1)
LVE: 103077074(VKORC1) 103091469(VKORC1L1)
OOR: 101271099(VKORC1L1) 101284991(VKORC1)
DLE: 111182082(VKORC1L1) 111182114(VKORC1)
PCAD: 102979206(VKORC1L1) 102984282(VKORC1)
PSIU: 116739769(VKORC1L1) 116740166(VKORC1)
NASI: 112399250(VKORC1L1) 112399311(VKORC1)
ECB: 100063360(VKORC1) 100629446(VKORC1L1)
EPZ: 103547239(VKORC1) 103558037(VKORC1L1)
EAI: 106831834(VKORC1L1) 106831891(VKORC1)
MYB: 102239240 102239782(VKORC1) 102255608(VKORC1L1) 102259131
MYD: 102764792(VKORC1L1) 102771765(VKORC1)
MMYO: 118656148(VKORC1) 118657014(VKORC1L1)
MLF: 102419906(VKORC1L1) 102435302(VKORC1)
PKL: 118702921(VKORC1L1) 118704943(VKORC1)
EFUS: 103286066(VKORC1L1) 103296237(VKORC1)
MNA: 107524390(VKORC1L1) 107540826(VKORC1)
DRO: 112304769(VKORC1) 112314697(VKORC1L1)
SHON: 118976266(VKORC1L1)
AJM: 119041138(VKORC1) 119055020(VKORC1L1)
PDIC: 114496038(VKORC1L1) 114506193(VKORC1)
PHAS: 123806404(VKORC1L1) 123825695(VKORC1)
MMF: 118641647(VKORC1L1) 118641657(VKORC1)
PPAM: 129078015(VKORC1) 129083738(VKORC1L1)
HAI: 109374189(VKORC1) 109376915(VKORC1L1)
RFQ: 117019671(VKORC1) 117025035(VKORC1L1)
PALE: 102880782(VKORC1L1) 102886750(VKORC1)
PGIG: 120591823(VKORC1L1) 120620061(VKORC1)
PVP: 105296731(VKORC1L1) 105304510(VKORC1)
RAY: 107503984(VKORC1) 107507444(VKORC1L1)
MJV: 108385526(VKORC1) 108408939(VKORC1L1)
TOD: 119241467(VKORC1L1) 119241709(VKORC1)
SARA: 101549306(VKORC1) 101549307(VKORC1L1)
SETR: 126030963(VKORC1) 126031275(VKORC1L1)
LAV: 100663455(VKORC1)
TMU: 101346924 101356156
ETF: 101652401(VKORC1L1) 101659528(VKORC1)
DNM: 101442019(VKORC1L1) 101445935(VKORC1)
MDO: 100010095(VKORC1L1) 100019247(VKORC1)
GAS: 123231144(VKORC1) 123244517(VKORC1L1)
SHR: 100914533(VKORC1) 100916214(VKORC1L1)
AFZ: 127558753 127562805
PCW: 110222147(VKORC1L1) 110223223(VKORC1)
OAA: 100085063(VKORC1) 103166981(VKORC1L1)
GGA: 408253(VKORC1L1)
PCOC: 116228113(VKORC1L1) 116240258
MGP: 100550207(VKORC1L1) 104915861
CJO: 107322449(VKORC1L1)
TPAI: 128083579(VKORC1L1)
LMUT: 125702833(VKORC1L1)
NMEL: 110391899 110407843(VKORC1L1)
APLA: 101798787(VKORC1L1)
ACYG: 106041424(VKORC1L1)
CATA: 118254206(VKORC1L1)
AFUL: 116497308(VKORC1L1)
TGU: 100230928(VKORC1L1)
LSR: 110481996(VKORC1L1) 110483486
SCAN: 103820095(VKORC1L1) 103824717
PMOA: 120507865(VKORC1L1) 120508519
OTC: 121344773 121345750(VKORC1L1)
PRUF: 121352738 121361665(VKORC1L1)
GFR: 102033623(VKORC1L1)
FAB: 101810261(VKORC1L1)
OMA: 130260918(VKORC1L1)
PHI: 102104161(VKORC1L1)
PMAJ: 107212753(VKORC1L1)
CCAE: 111922267 111937938(VKORC1L1)
CCW: 104691083(VKORC1L1)
CBRC: 103621523(VKORC1L1)
ETL: 114060508(VKORC1L1)
ZAB: 102075491(VKORC1L1)
ACHL: 103805953(VKORC1L1)
SVG: 106853357(VKORC1L1) 106864542
MMEA: 130586015(VKORC1L1) 130586976
HRT: 120761230(VKORC1L1)
FPG: 101920959(VKORC1L1)
CLV: 102085852(VKORC1L1)
EGZ: 104131820(VKORC1L1)
NNI: 104016793(VKORC1L1)
PCRI: 104027212(VKORC1L1)
PLET: 104625971(VKORC1L1)
EHS: 104505469(VKORC1L1)
PCAO: 104047897(VKORC1L1)
ACUN: 113487087(VKORC1L1)
TALA: 104366804(VKORC1L1)
PADL: 103925608(VKORC1L1)
AFOR: 103905889(VKORC1L1)
ACHC: 115338558 115347142(VKORC1L1)
HALD: 104324435(VKORC1L1)
HLE: 104835547(VKORC1L1)
AGEN: 126039126
GCL: 127024518 127027939
CCRI: 104159049(VKORC1L1)
CSTI: 104562308
CMAC: 104475505(VKORC1L1)
MUI: 104535578(VKORC1L1)
FGA: 104072260(VKORC1L1)
GSTE: 104255810(VKORC1L1)
LDI: 104349763
MNB: 103781915(VKORC1L1)
OHA: 104332795(VKORC1L1)
NNT: 104401361(VKORC1L1)
SHAB: 115602109(VKORC1L1) 115603062
DPUB: 104302817(VKORC1L1)
PGUU: 104462459 104471619
ACAR: 104522469(VKORC1L1)
AVIT: 104269803(VKORC1L1)
CVF: 104286546(VKORC1L1)
RTD: 128903532 128912790(VKORC1L1)
BRHI: 104489633(VKORC1L1)
AAM: 106495348(VKORC1L1)
AROW: 112961823 112978587(VKORC1L1)
NPD: 112945368(VKORC1L1)
TGT: 104567832(VKORC1L1)
DNE: 112987420
SCAM: 104144738(VKORC1L1)
ASN: 102373007(VKORC1L1) 112548693(VKORC1)
AMJ: 102575124(VKORC1L1) 102577367
CPOO: 109316933(VKORC1L1)
GGN: 109293442(VKORC1L1)
PSS: 102455189(VKORC1L1) 102455458
CMY: 102931890(VKORC1L1) 102937112
CCAY: 125623802(VKORC1L1) 125638107(VKORC1)
DCC: 119844451(VKORC1L1) 119857009
CPIC: 101932287(VKORC1L1) 101952869
TST: 117867437(VKORC1L1) 117888239
CABI: 116815531(VKORC1) 116821334(VKORC1L1)
MRV: 120387374(VKORC1L1) 120403351 120403473
ACS: 100555617(vkorc1)
ASAO: 132763447(VKORC1L1) 132777745(VKORC1)
PVT: 110084532(VKORC1L1) 110086404 110086406
SUND: 121916934(VKORC1L1) 121933336(VKORC1)
PBI: 103052312 103064445(VKORC1L1)
PMUR: 107287076(VKORC1L1) 107294319 107299076
CTIG: 120302294(VKORC1) 120309254(VKORC1L1)
TSR: 106543821(VKORC1L1) 106545499(VKORC1)
PGUT: 117666827(VKORC1) 117667535(VKORC1L1)
APRI: 131188870(VKORC1L1) 131196866(VKORC1)
PTEX: 113441564(VKORC1L1) 113449986(VKORC1)
NSS: 113414693(VKORC1L1) 113422509(VKORC1)
VKO: 123019596(VKORC1) 123036705(VKORC1L1)
PMUA: 114582862 114582863 114585928(VKORC1L1)
PRAF: 128399366(VKORC1) 128402640(VKORC1L1)
ZVI: 118094680(VKORC1) 118096703(VKORC1L1)
HCG: 128328742(VKORC1) 128335924 128336209
GJA: 107106645(VKORC1) 107112507(VKORC1L1)
STOW: 125444557(VKORC1) 125445465(VKORC1L1)
EMC: 129340535(VKORC1) 129344615(VKORC1L1)
XLA: 108709644(vkorc1l1.S) 398467(vkorc1.S) 733276(vkorc1l1.L)
XTR: 448775(vkorc1) 549523(vkorc1l1)
NPR: 108799191(VKORC1L1) 108800672
RTEM: 120926639(VKORC1L1) 120942978
BBUF: 120995518(VKORC1L1) 121007962
BGAR: 122931659(VKORC1L1) 122945556
MUO: 115456684(VKORC1L1) 115473952
GSH: 117349101(VKORC1L1) 117360752(VKORC1)
DRE: 100000559(vkorc1) 553717(vkorc1l1)
SRX: 107719344 107719575 107734370
SANH: 107654009 107654281(vkorc1l1) 107701846
SGH: 107563435 107598672
CCAR: 109051702 109058151 109081541
CAUA: 113068058 113070150 113070234 113070775 113112000
CGIB: 127958225 127969284 128014907
PTET: 122344903(vkorc1l1) 122355215 122361710
LROH: 127165280(vkorc1l1) 127173911(vkorc1)
OMC: 131540844(vkorc1l1) 131551078(vkorc1)
PPRM: 120468976(vkorc1) 120471681(vkorc1l1)
RKG: 130077417(vkorc1l1) 130080594(vkorc1)
MAMB: 125255907(vkorc1) 125266285(vkorc1l1)
CIDE: 127513116 127523718
MASI: 127422809 127423721 127433467
TROS: 130545486(vkorc1l1)
TDW: 130419180(vkorc1l1)
MANU: 129439534(vkorc1l1)
IPU: 100528488(vkorc1) 108259877
IFU: 128603894(vkorc1l1) 128616923(vkorc1)
PHYP: 113527539 113531399(vkorc1l1)
SMEO: 124378900(vkorc1l1) 124389036(vkorc1)
TFD: 113637233(vkorc1l1) 113653535(vkorc1)
TVC: 132841253 132841313(vkorc1l1) 132860245
TRN: 134303215(vkorc1l1) 134321645(vkorc1)
AMEX: 103029702 103037761
CMAO: 118809730(vkorc1) 118814753(vkorc1l1)
EEE: 113577552(vkorc1l1) 113591952
CHAR: 105892714(vkorc1) 105896063(vkorc1l1)
TRU: 115248692 446034(vkorc1) 446035(vkorc1l1)
TFS: 130522464(vkorc1) 130538001(vkorc1l1)
TNG: GSTEN00016275G001 GSTEN00028302G001
LCO: 104928769(vkorc1l1) 104935549
NCC: 104956341(vkorc1l1) 104967444
TBEN: 117469002(vkorc1l1) 117473349(vkorc1)
CGOB: 115018980(vkorc1l1) 115025109
PGEO: 117458239(vkorc1l1) 117464884(vkorc1)
GACU: 117544946(vkorc1) 117557292(vkorc1l1)
EMAC: 134871219(vkorc1) 134872442(vkorc1l1)
ELY: 117246706(vkorc1) 117267407(vkorc1l1)
EFO: 125880841(vkorc1) 125897940(vkorc1l1)
PLEP: 121952702(vkorc1l1) 121958389(vkorc1)
SLUC: 116058102(vkorc1l1) 116061570(vkorc1)
ECRA: 117937341(vkorc1) 117956082(vkorc1l1)
ESP: 116671110 116700533(vkorc1l1)
PFLV: 114548348 114566835(vkorc1l1)
GAT: 120819142(vkorc1) 120821346(vkorc1l1)
PPUG: 119212699(vkorc1) 119215732(vkorc1l1)
AFB: 129091359(vkorc1) 129113972(vkorc1l1)
CLUM: 117742435(vkorc1l1) 117748831(vkorc1)
PSWI: 130203808(vkorc1) 130212434(vkorc1l1)
MSAM: 119894921(vkorc1l1) 119915941(vkorc1)
SCHU: 122867176(vkorc1) 122888441(vkorc1l1)
CUD: 121518681(vkorc1l1) 121527885(vkorc1)
ALAT: 119009859(vkorc1) 119031576(vkorc1l1)
MZE: 101466626 101476827(vkorc1l1)
ONL: 100705457(vkorc1l1) 100706346
OAU: 116321898(vkorc1) 116324375(vkorc1l1)
OLA: 101166326(vkorc1l1) 101175272(vkorc1)
OML: 112142385(vkorc1l1) 112154204(vkorc1)
CSAI: 133419509(vkorc1) 133459815(vkorc1l1)
XMA: 102224968 102236035(vkorc1l1)
XCO: 114150296 114152577(vkorc1l1)
XHE: 116727136 116728597(vkorc1l1)
PRET: 103476055(vkorc1l1) 103481412
PFOR: 103133842(vkorc1l1) 103156839
PLAI: 106939030 106956650(vkorc1l1)
PMEI: 106908662 106934299(vkorc1l1)
GAF: 122823577(vkorc1) 122845224(vkorc1l1)
PPRL: 129368672(vkorc1l1) 129377672(vkorc1)
CVG: 107090350(vkorc1l1) 107097194
CTUL: 119775639(vkorc1l1) 119796754(vkorc1)
GMU: 124874787(vkorc1) 124876281(vkorc1l1)
NFU: 107387049(vkorc1l1) 107387978
KMR: 108233845(vkorc1l1) 108237265(vkorc1)
ALIM: 106521363 106525412(vkorc1)
NWH: 119420067(vkorc1l1) 119423595(vkorc1)
AOCE: 111572720(vkorc1l1) 111581582
MCEP: 125021070(vkorc1l1) 125022023(vkorc1)
CSEM: 103382040 103394913(vkorc1l1)
POV: 109628628(vkorc1l1) 109646209
SSEN: 122762756(vkorc1) 122780047(vkorc1l1)
HHIP: 117752784(vkorc1) 117774060(vkorc1l1)
HSP: 118101059(vkorc1) 118121755(vkorc1l1)
PPLT: 128426297(vkorc1) 128457297(vkorc1l1)
SMAU: 118287274(vkorc1) 118300400(vkorc1l1)
LCF: 108884459 108893410
SDU: 111220323 111222156(vkorc1l1)
SLAL: 111658706 111663852(vkorc1l1)
XGL: 120794874(vkorc1) 120802311(vkorc1l1)
HCQ: 109508799(vkorc1l1) 109524007
SSCV: 125982417 125990938
SBIA: 133491556(vkorc1l1) 133496041(vkorc1)
PEE: 133416473(vkorc1l1) 133418010(vkorc1)
PTAO: 133466975(vkorc1l1) 133469701(vkorc1)
BPEC: 110159643 110165064(vkorc1l1)
MALB: 109960444(vkorc1l1) 109963618
BSPL: 114845530(vkorc1) 114869075(vkorc1l1)
SJO: 128371141(vkorc1l1) 128381314(vkorc1)
SASA: 106567394(vkorc1l1) 106577046
STRU: 115148425(vkorc1l1) 115193702
OTW: 112253079(vkorc1) 112258348 121841387
OMY: 110529490(vkorc1) 110537845 118966696
OGO: 123999324 124014982 124040746(vkorc1)
ONE: 115105380 115136237 115136328
OKI: 109873325 109888802 109893037
OKE: 118369922(vkorc1) 118389754 118390998
SALP: 111951604 111963498 111980926
SNH: 120017939(vkorc1) 120032726 120056816
CCLU: 121553508(vkorc1) 121574101 121579132(vkorc1l1) 123482454
ELS: 105007720 105008282(vkorc1l1)
SFM: 108921596(vkorc1l1) 108938295 108941679
PKI: 111836830 111854712(vkorc1l1) 111859697
AANG: 118209798 118220282(vkorc1) 118235633(vkorc1l1)
LOC: 102693652(vkorc1l1) 102696686
PSPA: 121305140 121308568(vkorc1l1)
ARUT: 117398336 117429891 117430605
PSEX: 120519621(vkorc1) 120531418(vkorc1l1)
LCM: 102345266(VKORC1L1) 102357927
CMK: 103180624(vkorc1l1)
RTP: 109928519(vkorc1l1)
CPLA: 122542369 122564075(vkorc1l1)
HOC: 132808900 132830528(vkorc1l1)
LERI: 129710805(vkorc1l1)
PMRN: 116936876 116939185
BFO: 118425571 118426307
BBEL: 109463634 109466245
CIN: 100178185 780870(vkor)
SPU: 763699
LPIC: 129254799
APLC: 110988312
AJC: 117116267
SKO: 100376428 102805472
DME: Dmel_CG33544(Vkor)
DER: 6548496
DSE: 6609493
DSI: Dsimw501_GD11216(Dsim_GD11216)
DYA: Dyak_GE11817
DSR: 110180445
DPO: 6899093
DPE: 6601584
DMN: 108158370 117192983
DWI: 6640946
DGR: 6571186
DMO: Dmoj_GI21152
DNV: 108653874
DHE: 111594945
CCAT: 101455423
BOD: 106617881
BDR: 105226676
RZE: 108368062
AOQ: 129245533
TDA: 119683711
MDE: 101888998
SCAC: 106088686
LCQ: 111682432
LSQ: 119607419
GFS: 119636317
ECOE: 129947933
CLON: 129605458
HIS: 119657085
AGA: 1271615
ACOZ: 120956807
AARA: 120906674
AMER: 121597631
ASTE: 118511958
AFUN: 125767986
AMOU: 128307181
AALI: 118460223
AAG: 5574649
AALB: 109415799 109431186
CQU: CpipJ_CPIJ003816
CPII: 120430280
CNS: 116344816
BCOO: 119083430
AME: 724791
ACER: 107995061
ALAB: 122718185
ADR: 102677293
AFLR: 100872042
BIM: 100746180
BBIF: 117207068
BVK: 117237317
BVAN: 117160893
BTER: 100647907
BAFF: 126917871
BPYO: 122572804
BPAS: 132907303
FVI: 122532552
CCAL: 108622863
OBB: 114878863
MGEN: 117229918
NMEA: 116428177
CGIG: 122404484
SOC: 105199915
MPHA: 105838573
AEC: 105148077
ACEP: 105624125
PBAR: 105423896
VEM: 105565949
HST: 105189853
DQU: 106741085
CFO: 105256425
FEX: 115240480
LHU: 105671028
PGC: 109856097
OBO: 105284994
PCF: 106790230
PFUC: 122513406
VPS: 122637170
VCRB: 124431200
VVE: 124957148
NVI: 100121150
CSOL: 105364056
TPRE: 106654656
LHT: 122510351
LBD: 127283293
MDL: 103578951
CGLO: 123271579
FAS: 105264909
DAM: 107043343
AGIF: 122851518
VCAN: 122407524
CCIN: 107272607
DSM: 124407860
NPT: 124217205
NFB: 124180621
NLO: 107218685
NVG: 124303227
AROA: 105688833
TCA: 103315249
DPA: 109544649
SOY: 115879210
AGRG: 126737622
ATD: 109609280
CSET: 123317026
AGB: 108912240
DVV: 114328066
NVL: 108562475
APLN: 112906499
PPYR: 116177948
OTU: 111426474
BMOR: 101746818
BMAN: 114252611
MSEX: 115456116
DPL: KGM_206433
BANY: 112044458
MJU: 123872599
NIQ: 126773741
VCD: 124534157
MCIX: 123656458
PMAC: 106717878
PPOT: 106108589
PXU: 106115825
PRAP: 111003414
PBX: 123709376
PNAP: 125048649
ZCE: 119830629
CCRC: 123695995
LSIN: 126977427
AAGE: 121733311
HAW: 110374796
HZE: 124637883
TNL: 113498914
SLIU: 111347859
OFU: 114360700
PXY: 105381639
PGW: 126372056
CFEL: 113376005 113386337
CCRN: 123292839
API: 100573656 103309105
DNX: 107161956
AGS: 114121307
RMD: 113554155
ACOO: 126840747
DVT: 126893585
BTAB: 109041108
DCI: 103511493 103511494
CLEC: 106663678
HHAL: 106689846
NLU: 111046624 120355860
HVI: 124367190 124367217
PHU: Phum_PHUM098450
FOC: 113207895
TPAL: 117645287
ZNE: 110831183
CSEC: 111873453
SGRE: 126284065
BROR: 134530118
IEL: 124157570
FCD: 110856806
DPX: DAPPUDRAFT_304442
DMK: 123471513
DPZ: 124336485
PVM: 113823507
PJA: 122260330
PCHN: 125025702
PMOO: 119577042
HAME: 121875687
PCLA: 123764994
CQD: 128692067
PTRU: 123518769
ESN: 126987733
MNZ: 135220824
HAZT: 108676735
EAF: 111699917
LSM: 121122276
TCF: 131880885
DSV: 119446301
RSAN: 119389877
RMP: 119175932
VDE: 111251999
VJA: 111260006
TUT: 107362817
DPTE: 113792512
DFR: 124497101
CSCU: 111629235
PTEP: 107451341
ABRU: 129969131
SDM: 118196454
LPOL: 106465429
PMEO: 129595072
BMY: BM_BM605(Bm605)
LOA: LOAG_06369
HRO: HELRODRAFT_88258
LGI: LOTGIDRAFT_114833 LOTGIDRAFT_115113
PVUL: 126823478 126823479
PCAN: 112561177 112562931
BGT: 106056179 106056190
GAE: 121369461 121390761
HRF: 124147730 124147731
HRJ: 124286966 124286967
CRG: 105338127
CVN: 111136434
CANU: 128188912
OED: 125674842
MYI: 110460140
PMAX: 117333684
MCAF: 127710581
MMER: 123535186
RPHI: 132715536
OBI: 106870276 106877249
OSN: 115222593 115224536
LAK: 106150415 106150416
NVE: 5506957 5515586
EPA: 110250868
ATEN: 116292045 116293954
ADF: 107340505
AMIL: 114960653
PDAM: 113676685
SPIS: 111331307
DGT: 114520441
XEN: 124433813
HMG: 101235337
HSY: 130645204
TAD: TRIADDRAFT_6927
AQU: 100633778
MBR: MONBRDRAFT_29821
SRE: PTSG_04186
TGO: TGME49_203720 TGME49_249760
FCY: FRACYDRAFT_267199
PSOJ: PHYSODRAFT_472863
EHX: EMIHUDRAFT_361809 EMIHUDRAFT_440728
GTT: GUITHDRAFT_106868
TBR: Tb927.2.4840
TBG: TbgDal_II2880
TCR: 504741.190
LMA: LMJF_27_2190
LIF: LINJ_27_2110
LDO: LDBPK_272110
LMI: LMXM_27_2190
LBZ: LBRM_27_2370
LPAN: LPMP_272190
ACA: ACP_3002
ACM: AciX9_0903
GRW: FTO74_03180
TRS: Terro_1053
ABAS: ACPOL_1085
 » show all
Reference
1  [PMID:646989]
  Authors
Whitlon DS, Sadowski JA, Suttie JW.
  Title
Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition.
  Journal
Biochemistry 17:1371-7 (1978)
DOI:10.1021/bi00601a003
Reference
2  [PMID:6733086]
  Authors
Lee JJ, Fasco MJ.
  Title
Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide.
  Journal
Biochemistry 23:2246-52 (1984)
DOI:10.1021/bi00305a024
Reference
3  [PMID:3857611]
  Authors
Mukharji I, Silverman RB.
  Title
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone.
  Journal
Proc Natl Acad Sci U S A 82:2713-7 (1985)
DOI:10.1073/pnas.82.9.2713
Reference
4  [PMID:14765195]
  Authors
Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW
  Title
Identification of the gene for vitamin K epoxide reductase.
  Journal
Nature 427:541-4 (2004)
DOI:10.1038/nature02254
Reference
5  [PMID:17124179]
  Authors
Wajih N, Hutson SM, Wallin R
  Title
Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction.
  Journal
J Biol Chem 282:2626-35 (2007)
DOI:10.1074/jbc.M608954200
Reference
6  [PMID:19492146]
  Authors
Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Muller C, Paulsson M, Bruning JC, Oldenburg J
  Title
VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding.
  Journal
Thromb Haemost 101:1044-50 (2009)
Reference
7  [PMID:20696932]
  Authors
Schulman S, Wang B, Li W, Rapoport TA
  Title
Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners.
  Journal
Proc Natl Acad Sci U S A 107:15027-32 (2010)
DOI:10.1073/pnas.1009972107
Other DBs
ExplorEnz - The Enzyme Database: 1.17.4.4
IUBMB Enzyme Nomenclature: 1.17.4.4
ExPASy - ENZYME nomenclature database: 1.17.4.4
BRENDA, the Enzyme Database: 1.17.4.4
CAS: 55963-40-1
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