KEGG   ENZYME: 1.17.98.3
Entry
EC 1.17.98.3                Enzyme                                 
Name
formate dehydrogenase (coenzyme F420);
coenzyme F420 reducing formate dehydrogenase;
coenzyme F420-dependent formate dehydrogenase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With other, known, physiological acceptors
Sysname
formate:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
formate + oxidized coenzyme F420 = CO2 + reduced coenzyme F420 [RN:R10797]
Reaction(KEGG)
R10797
Substrate
formate [CPD:C00058];
oxidized coenzyme F420 [CPD:C00876]
Product
CO2 [CPD:C00011];
reduced coenzyme F420 [CPD:C01080]
Comment
The enzyme, characterized from methanogenic archaea, is involved in formate-dependent H2 production. It contains noncovalently bound FAD [1].
History
EC 1.17.98.3 created 2014 as EC 1.2.99.9, transferred 2017 to EC 1.17.98.3
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00125  formate dehydrogenase (coenzyme F420) beta subunit
K22516  formate dehydrogenase (coenzyme F420) alpha subunit
Genes
VNA: PN96_21155
VEJ: VEJY3_20411
VJP: NP165_14560(fdhF)
PGB: H744_1c0419
PGH: FH974_23235(fdhF)
PCH: EY04_14750
PPHN: HU825_03470(fdhF)
PSH: Psest_3905
PSTU: UIB01_19765
PSED: DM292_16890
SDEG: GOM96_08860
GNI: GNIT_2862
ALII: QR722_09955(fdhF)
TMB: Thimo_0255
CHIZ: HQ393_09255
CFON: HZU75_11945
SUTT: SUTMEG_11560
SUTK: FG381_06445
NPV: OHM77_12825
SLAC: SKTS_06260
BLAG: BLTE_14910
RAP: RHOA_4366
CCO: CCC13826_0200(fdhH)
CCOC: CCON33237_0536(fdhH)
CGRA: CGRAC_1361(fdhH)
CPIN: CPIN18020_0262(fdhH)
CGEO: CGEO_1649(fdhH)
CMUC: CMCT_1635(fdhH)
CSHO: CSHOW_0456(fdhH)
SULS: Sdiek1_1063
SULJ: SJPD1_1032
AHS: AHALO_1025(fdhH)
AMAR: AMRN_1963(fdhH)
ACAA: ACAN_2017(fdhH)
CMED: FE773_08405
GSU: GSU0088(hdrD)
GSK: KN400_0063(hdrD)
GME: Gmet_3428(hdrD)
GPI: GPICK_06770 GPICK_15705
GAO: A2G06_16000
GBZ: JZM60_06200 JZM60_10225(fdhF)
GEM: GM21_0027
GEB: GM18_0024 GM18_3241
GEF: FO488_02625
GUR: Gura_0147
GEO: Geob_0149 Geob_3720(hdrD)
TAMM: GEAMG1_2371(hdrD)
GBM: Gbem_0028(hdrD)
GBN: GEOBRER4_00260(hdrD)
GER: KP004_19730
GSUB: KP001_16585
GNT: KP003_19720
GPL: M1B72_00020
PCA: Pcar_2701
PPD: Ppro_2790 Ppro_2799
DVE: DESUT3_05340
DFL: DFE_0758 DFE_2489
DMA: DMR_01940
DCB: C3Y92_00575
DGG: DGI_1052(floxC)
DDE: Dde_1211 Dde_3528
DMS: E8L03_02850
DSA: Desal_0598
DHY: DESAM_21328
DAF: Desaf_1864 Desaf_2879
DAS: Daes_0781
DPI: BN4_11862
DEJ: AWY79_07305
PSEL: GM415_15615
DDN: DND132_1390 DND132_2347
PPOR: JCM14722_30760
PNW: SYK_07300
PTHE: LF599_14190
DSX: GD604_05900 GD604_12445
DSD: GD606_00175 GD606_07840 GD606_11690
DBA: Dbac_2346
DOA: AXF15_00785 AXF15_11190
DESU: NLA06_01255
DRT: Dret_0419
DSF: UWK_03159
DLM: DPPLL_12850 DPPLL_25470(hdrD) DPPLL_25480
ECOM: QTN59_02640
DAL: Dalk_5062
DAT: HRM2_11880(fdhA3) HRM2_14370(fdhA4) HRM2_22080(fdhB5) HRM2_22740(fdhB6)
DTO: TOL2_C17890 TOL2_C24200
DOV: DSCO28_26720 DSCO28_27580 DSCO28_27830 DSCO28_36090 DSCO28_48980 DSCO28_65560
DWD: DSCW_21250 DSCW_47550 DSCW_60930 DSCW_61120
DALK: DSCA_54490 DSCA_54710 DSCA_62380(hdrD)
DML: Dmul_02420
DMM: dnm_011400 dnm_084970
DEK: DSLASN_12960
DTI: Desti_4266
SFU: Sfum_0822 Sfum_1972
DAX: FDQ92_05250 FDQ92_10770
DBR: Deba_2134
DMP: FAK_06900
TID: Thein_2071
TAV: G4V39_00755 G4V39_00795
EFS: EFS1_1216
ENE: ENT_08450
CSQ: CSCA_0253
CEU: A7L45_12260
CDRK: B9W14_17240
CTHD: CDO33_09930
RCH: RUM_11000
RUM: CK1_05080
SMAN: C12CBH8_20570
SWO: Swol_0400
SALQ: SYNTR_0266
DSY: DSY1990
DHD: Dhaf_3153
DDH: Desde_2607
SGY: Sgly_1898
DOR: Desor_0108 Desor_2815 Desor_3508
DAI: Desaci_2628
DMI: Desmer_2224
DCA: Desca_0132 Desca_0138 Desca_0819
PTH: PTH_1407(RnfC)
DRM: Dred_0139 Dred_0146 Dred_1330
DRU: Desru_0208 Desru_0215 Desru_2695
DFG: B0537_01500 B0537_01535 B0537_06305 B0537_08745
DAE: Dtox_1279 Dtox_1355
DKU: Desku_0190 Desku_1432 Desku_1482
DAU: Daud_0567
TFR: BR63_02785 BR63_09665
FWA: DCMF_10300 DCMF_16640 DCMF_24650
TJR: TherJR_0939 TherJR_1951 TherJR_2471
DGI: Desgi_0611 Desgi_0612 Desgi_2044
HMO: HM1_2010
HCV: FTV88_1706
CTHM: CFE_1626
BYL: A4V09_16705
BPRO: PMF13cell1_01674
BLAB: EYS05_14060
BWX: NQ550_09275
BMAS: LK422_09985
BLAR: LC508_15280
BLUI: Blut17040_18850
BCOC: BLCOC_07560
MFOR: NQ534_19220
CMIU: B1H56_01495
CHY: CHY_0932
ADG: Adeg_1331
MAS: Mahau_0897
BACG: D2962_12430
NTH: Nther_2660
AAR: Acear_0635
ABAT: CFX1CAM_1232
PSUB: Pelsub_P0987
FPES: NXS98_05995
BPIT: BPIT_11130
PBAP: Pla133_02470(fdhF)
TBE: Trebr_2032
FVA: FV113G1_17800
FUL: C4N20_13335
IPO: Ilyop_2562
CPOR: BED41_00295
DTE: Dester_1341
TTK: TST_1517 TST_1524
MJA: MJ_0005 MJ_0006
MFE: Mefer_0653 Mefer_0654 Mefer_1009
MVU: Metvu_0710 Metvu_0711 Metvu_1163
MFS: MFS40622_0206 MFS40622_0207 MFS40622_0235 MFS40622_0236
MJH: JH146_0247 JH146_0280 JH146_0281
MESG: MLAUSG7_0307 MLAUSG7_0837(fdhB) MLAUSG7_0838
MESA: MLASG1_0357 MLASG1_0358(fdhB) MLASG1_1372
MIG: Metig_0762 Metig_1191 Metig_1192
MMP: MMP0138(fdhA) MMP0139(fdhB) MMP1297(fdhB) MMP1298(fdhA)
MMQ: MmarC5_0295 MmarC5_0296 MmarC5_1537 MmarC5_1538
MMX: MmarC6_0813 MmarC6_0814 MmarC6_1376 MmarC6_1377
MMZ: MmarC7_0542 MmarC7_0543 MmarC7_1137 MmarC7_1138
MMD: GYY_00710 GYY_07320
MMAK: MMKA1_01430(fdhA) MMKA1_01440(fdhB) MMKA1_15220(fdhB) MMKA1_15230(fdhA)
MMAO: MMOS7_01690(fdhA) MMOS7_01700(fdhB) MMOS7_14040(fdhB) MMOS7_14050(fdhA)
MMAD: MMJJ_09460 MMJJ_09470(fdhF_2) MMJJ_15440(fdhA2) MMJJ_15460(fdhB1)
MAE: Maeo_0577 Maeo_0578
MVN: Mevan_0607 Mevan_0608 Mevan_1144
MVO: Mvol_0702 Mvol_0703 Mvol_0818 Mvol_0819
MOK: Metok_0188 Metok_0189 Metok_1223 Metok_1224
MTH: MTH_1139 MTH_1140
MMG: MTBMA_c15220(fdhB) MTBMA_c15230(fdhA2)
MWO: MWSIV6_0697(fdhA5) MWSIV6_0698(fdhB1) MWSIV6_1531(fdhB3) MWSIV6_1532
MTEE: MTTB_12340
METC: MTCT_1032 MTCT_1033 MTCT_1438 MTCT_1439
METE: tca_01095 tca_01096
METK: FVF72_05885 FVF72_05890
MTHM: FZP57_03345 FZP57_03350 FZP57_07330 FZP57_07335
METJ: FZP68_03340 FZP68_03345
MST: Msp_0639(fdhB) Msp_0640(fdhA)
METB: AW729_02755 AW729_02760
MEIS: PXD04_07905 PXD04_07910
MRU: mru_0333(fdhA1) mru_0334(fdhB1) mru_2074(fdhA2) mru_2075(fdhB2)
MSI: Msm_1404 Msm_1405 Msm_1462 Msm_1463
MEB: Abm4_0131(fdhA) Abm4_0132(fdhB) Abm4_0854(fdhB2) Abm4_0855(fdhA2)
MMIL: sm9_1349(flpB) sm9_1350(flpA) sm9_2182(fdhB) sm9_2183(fdhA)
MEYE: TL18_00925 TL18_01670 TL18_01675
MOL: YLM1_0030 YLM1_0031 YLM1_1105 YLM1_1106 YLM1_1539 YLM1_1540
MARO: MarbSA_13560 MarbSA_13570
METV: K4897_04270 K4897_04275(fdhF) K4897_08135 K4897_08140
MEW: MSWAN_0113 MSWAN_0115 MSWAN_0116
METH: MBMB1_0103(fdhB) MBMB1_0104(fdhA)
MFC: BRM9_0167(fdhB) BRM9_0168(fdhA)
MFI: DSM1535_1485(fdhB) DSM1535_1486(fdhA)
MCUB: MCBB_2028(fdhA) MCBB_2029(fdhB1) MCBB_2031(fdhB3)
MSUB: BK009_10240 BK009_10250 BK009_10255
METN: BK008_05865 BK008_05875 BK008_05880
METT: CIT01_01075 CIT01_01080
METO: CIT02_06500 CIT02_06505
MFEG: GCM10025860_09590 GCM10025860_09600 GCM10025860_11680 GCM10025860_11690 GCM10025860_14940 GCM10025860_14950
MFV: Mfer_0694 Mfer_0695 Mfer_0725 Mfer_0726
MKA: MK0321 MK0322
AVE: Arcve_2107
AST: Asulf_01818
FPL: Ferp_0094
PYN: PNA2_1925
PYA: PYCH_11030
PYS: Py04_1234
PYC: TQ32_09760 TQ32_10390
TKO: TK2076
TON: TON_0539 TON_1563
TGA: TGAM_0065(mhy2A) TGAM_0631(fdhA)
TSI: TSIB_0067
TBA: TERMP_00460
THE: GQS_02455 GQS_05815
THA: TAM4_610
THM: CL1_0794 CL1_1148
TLT: OCC_06696 OCC_12236
THS: TES1_1496
TNU: BD01_1760 BD01_1899
TEU: TEU_00760
THV: ADU37_CDS22830
TCH: CHITON_1559
TPIE: A7C91_04320 A7C91_08750
TCE: A3L02_01395
TBS: A3L01_00065
THH: CDI07_00115
TSL: A3L11_03805
TTD: A3L14_01350
TPRF: A3L09_08935
TRL: A3L10_09785
TPAF: A3L08_06500
THY: A3L12_01285
TIC: FH039_02070 FH039_05990
TCQ: TIRI35C_0225(fdhA)
THEM: FPV09_03360 FPV09_07205
THEI: K1720_03400(fdhF)
PPAC: PAP_03230
MBA: Mbar_A1561 Mbar_A1562
MBY: MSBRM_2895 MSBRM_2896
MBW: MSBRW_3168 MSBRW_3169
MBAR: MSBR2_2854 MSBR2_2855
MMAC: MSMAC_2581 MSMAC_2582
METM: MSMTP_1177
MEF: MSWH1_2086
MEQ: MSWHS_3009
MHOR: MSHOH_1794 MSHOH_1795
MPY: Mpsy_2943 Mpsy_2944
MSEB: RE474_01395 RE474_01400
MEHF: MmiHf6_05660 MmiHf6_05670
MEES: MmiEs2_04350 MmiEs2_04360
MTP: Mthe_1339
MCJ: MCON_2237(fdhA)
MHI: Mhar_0324 Mhar_0325 Mhar_1282 Mhar_1628 Mhar_1941
MHU: Mhun_1813 Mhun_1814 Mhun_1832 Mhun_1833 Mhun_2020 Mhun_2021 Mhun_2022 Mhun_2023 Mhun_3237 Mhun_3238
MRTJ: KHC33_00530(fdhF) KHC33_00535 KHC33_05240(fdhF) KHC33_05245 KHC33_05335 KHC33_05340(fdhF) KHC33_10635 KHC33_10640(fdhF) KHC33_14310(fdhF) KHC33_14315 KHC33_14320(fdhF) KHC33_14325
MLA: Mlab_0462 Mlab_0463 Mlab_1057 Mlab_1058
MEM: Memar_1044 Memar_1045 Memar_1378 Memar_1379 Memar_1380 Memar_1381 Memar_1623 Memar_1624
MBG: BN140_0841(fdhB) BN140_0842(fdhA) BN140_1327(fdhA1) BN140_1328(fdhB1) BN140_1329(fdhA2) BN140_1330(fdhB2) BN140_2197(fdhB3) BN140_2198(fdhA3)
MEMA: MMAB1_1105(fdhB) MMAB1_1106(fdhA) MMAB1_1689(fdhA) MMAB1_1690(fdhB) MMAB1_2913(fdhB) MMAB1_2914(fdhA)
MCHK: MchiMG62_11690 MchiMG62_11700 MchiMG62_15750 MchiMG62_15760 MchiMG62_15770 MchiMG62_15780 MchiMG62_17900 MchiMG62_17910
MSUM: OH143_01115 OH143_01120(fdhF) OH143_01125 OH143_01130(fdhF) OH143_02325 OH143_02330(fdhF) OH143_11945 OH143_11950(fdhF)
MRC: R6Y96_05800(fdhF) R6Y96_05805 R6Y96_06465(fdhF) R6Y96_06470
MPI: Mpet_1035 Mpet_1036 Mpet_1047 Mpet_1048 Mpet_1627 Mpet_1628
MEND: L6E24_11840(fdhF) L6E24_11845
MEFW: F1737_05525 F1737_05530 F1737_05550 F1737_05555
MAQE: RJ40_03445 RJ40_03450
MFK: E2N92_03500 E2N92_03505
MOU: OU421_01580(fdhF) OU421_01585 OU421_03545
MESB: L1S32_05095(fdhF) L1S32_05100 L1S32_07140 L1S32_07145
MANQ: L1994_04160 L1994_04165 L1994_05185 L1994_05190(fdhF)
MBN: Mboo_0923 Mboo_0924
MFO: Metfor_0647 Metfor_0648 Metfor_0650 Metfor_0651 Metfor_0677 Metfor_0678
MPL: Mpal_0195 Mpal_0196 Mpal_0577 Mpal_0578
MPD: MCP_1569(fdhB-1) MCP_1570(fdhA-1) MCP_2406(fdhB-2) MCP_2407(fdhA-2)
MEZ: Mtc_2124(fdhB) Mtc_2125(fdhA)
RCI: RCIX1628(fdhA-1) RCIX1630(fdhB-1) RCIX2372(fdhB-2) RCIX2373(fdhA-2) RCIX2376(fdhB-3) RCIX2378(fdhA-3) RRC251(fdhA-4) RRC252(fdhB-4)
HHB: Hhub_2705(fdhA)
HNO: LT974_10300(fdhF)
HALH: HTSR_1736(fdhA) HTSR_1740(fdhA2)
HHSR: HSR6_1802(fdoG2) HSR6_1806(fdoG3)
HJE: HacjB3_08400
HARA: AArcS_1771(yjgC)
HHI: HAH_5041(fdhA)
HHN: HISP_18370
HAB: SG26_17860
NMO: Nmlp_2714(fdhA)
HALI: BV210_11270
SSAI: N0B31_21065(fdhF)
HAQ: DU484_02900 DU484_17375
HAJ: DU500_00415 DU500_03330
HAER: DU502_01085 DU502_15800
HRA: EI982_15430
HLM: DV707_15380
HLA: Hlac_1238
HALP: DOS48_05995
HALB: EKH57_00640 EKH57_15440
HEZZ: EO776_02790
HALQ: Hrr1229_013155(fdhF)
HSS: J7656_05930(fdhF) J7656_13980(fdhF)
HSAI: HPS36_11145(fdhF)
HAZZ: KI388_08835(fdhF)
SRUB: C2R22_06085
HALU: HUG12_20610(fdhF)
HRM: K6T25_13375(fdhF)
HDF: AArcSl_0465(fdoG) AArcSl_1489(fdoG2)
HTU: Htur_0685
HSAL: JMJ58_05665(fdhF)
HXA: Halxa_0835
NPE: Natpe_2904
NAY: HYG81_16490(fdhF)
HALY: HYG82_00570(fdhF)
HJT: DVR14_04645
NGE: Natgr_0651 Natgr_2918
NOU: Natoc_1422
HLC: CHINAEXTREME08970
NAJ: B1756_07310 B1756_16645
NAG: AArcMg_0491
NAN: AArc1_0503
NARA: QQ977_13275(fdhF)
NBG: DV706_17960
NAS: GCU68_09540
TAC: Ta0045
TVO: TVG0003442(TVG0003442)
FAC: FACI_IFERC01G0549
FAI: FAD_1471
ABI: Aboo_0808 Aboo_0980
ACF: AciM339_1138
SHC: Shell_0724
IHO: Igni_1101
IIS: EYM_07315
PFM: Pyrfu_0745
AHO: Ahos_2012
AAMB: D1866_05085
VDI: Vdis_2449
TPE: Tpen_0190
FFO: FFONT_1292
LOKI: Lokiarch_00320(fdhB) Lokiarch_42530
LOB: NEF87_000179
PSYT: DSAG12_02784(fdhB_1) DSAG12_03719(fdhB_2)
 » show all
Reference
1  [PMID:6874636]
  Authors
Schauer NL, Ferry JG
  Title
FAD requirement for the reduction of coenzyme F420 by formate dehydrogenase from  Methanobacterium formicicum.
  Journal
J Bacteriol 155:467-72 (1983)
DOI:10.1128/JB.155.2.467-472.1983
Reference
2  [PMID:3944055]
  Authors
Schauer NL, Ferry JG
  Title
Composition of the coenzyme F420-dependent formate dehydrogenase from Methanobacterium formicicum.
  Journal
J Bacteriol 165:405-11 (1986)
DOI:10.1128/JB.165.2.405-411.1986
Reference
3  [PMID:18791018]
  Authors
Lupa B, Hendrickson EL, Leigh JA, Whitman WB
  Title
Formate-dependent H2 production by the mesophilic methanogen Methanococcus maripaludis.
  Journal
Appl Environ Microbiol 74:6584-90 (2008)
DOI:10.1128/AEM.01455-08
Other DBs
ExplorEnz - The Enzyme Database: 1.17.98.3
IUBMB Enzyme Nomenclature: 1.17.98.3
ExPASy - ENZYME nomenclature database: 1.17.98.3
BRENDA, the Enzyme Database: 1.17.98.3
LinkDB

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