Entry
Name
limonene dehydrogenase;
ctmAB (gene names)
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With unknown physiological acceptors
BRITE hierarchy
Sysname
limonene:acceptor oxidoreductase (7-hydroxylating)
Reaction(IUBMB)
(1) (S)-limonene + H2O + acceptor = (-)-perillyl alcohol + reduced acceptor [RN:
R12591 ];
(2) (R)-limonene + H2O + acceptor = (+)-perillyl alcohol + reduced acceptor [RN:
R12592 ]
Reaction(KEGG)
Substrate
Product
(-)-perillyl alcohol [CPD:
C02452 ];
reduced acceptor [CPD:
C00030 ];
(+)-perillyl alcohol [CPD:
C22272 ]
Comment
Contains FAD. The enzyme, characterized from the bacterium Castellaniella defragrans 65Phen, hydroxylates the R- and S-enantiomers at a similar rate. The in vivo electron acceptor may be a heterodimeric electron transfer flavoprotein (ETF).
History
EC 1.17.99.8 created 2020
Orthology
Genes
CDN : BN940_14221 BN940_14226
Taxonomy
Reference
Authors
Petasch J, Disch EM, Markert S, Becher D, Schweder T, Huttel B, Reinhardt R, Harder J
Title
The oxygen-independent metabolism of cyclic monoterpenes in Castellaniella defragrans 65Phen.
Journal
Sequence
Reference
Authors
Puentes-Cala E, Liebeke M, Markert S, Harder J
Title
Limonene dehydrogenase hydroxylates the allylic methyl group of cyclic monoterpenes in the anaerobic terpene degradation by Castellaniella defragrans.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.17.99.8
LinkDB
All DBs