Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

propanal:NAD+ oxidoreductase (CoA-propanoylating)

propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+ [RN:R09097]

R09097;
(other) R01172
Reaction

propanal [CPD:C00479];
CoA [CPD:C00010];
NAD+ [CPD:C00003]

The enzyme forms a bifunctional complex with EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase, with a tight channel connecting the two subunits [1,2,3]. Also acts, more slowly, on glycolaldehyde and butanal. In Pseudomonas species the enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). NADP+ can replace NAD+ with a much slower rate [3].

EC 1.2.1.87 created 2013

1  [PMID:19476337]

2  [PMID:21838275]

3  [PMID:22316175]