KEGG   ENZYME: 1.21.3.8
Entry
EC 1.21.3.8                 Enzyme                                 
Name
cannabidiolic acid synthase;
CBDA synthase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
Sysname
cannabigerolate:oxygen oxidoreductase (cyclizing, cannabidiolate-forming)
Reaction(IUBMB)
cannabigerolate + O2 = cannabidiolate + H2O2 [RN:R10160]
Reaction(KEGG)
R10160
Substrate
cannabigerolate [CPD:C20406];
O2 [CPD:C00007]
Product
cannabidiolate [CPD:C10784];
H2O2 [CPD:C00027]
Comment
Binds FAD covalently. Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also convert cannabinerolate to cannabidiolate with lower efficiency.
History
EC 1.21.3.8 created 2012
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20502  cannabidiolic acid synthase
Genes
CSAV115697762
Reference
1  [PMID:8663284]
  Authors
Taura F, Morimoto S, Shoyama Y
  Title
Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid.
  Journal
J Biol Chem 271:17411-6 (1996)
DOI:10.1074/jbc.271.29.17411
  Sequence
Reference
2  [PMID:17544411]
  Authors
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  Title
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  Journal
FEBS Lett 581:2929-34 (2007)
DOI:10.1016/j.febslet.2007.05.043
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.21.3.8
IUBMB Enzyme Nomenclature: 1.21.3.8
ExPASy - ENZYME nomenclature database: 1.21.3.8
BRENDA, the Enzyme Database: 1.21.3.8
LinkDB

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