KEGG ENZYME: 1.21.99.1

ENZYME: 1.21.99.1

Entry

EC 1.21.99.1                Enzyme

Name

beta-cyclopiazonate dehydrogenase;
beta-cyclopiazonate oxidocyclase;
beta-cyclopiazonic oxidocyclase;
beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)

Class

Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With unknown physiological acceptors

Sysname

beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)

Reaction(IUBMB)

beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor [RN:R04080]

Reaction(KEGG)

R04080

Substrate

beta-cyclopiazonate [CPD:C02899];
acceptor [CPD:C00028]

Product

alpha-cyclopiazonate [CPD:C03032];
reduced acceptor [CPD:C00030]

Comment

A flavoprotein (FAD). Cytochrome c and various dyes can act as acceptor. Cyclopiazonate is a microbial toxin.

History

EC 1.21.99.1 created 1976 as EC 1.3.99.9, transferred 2002 to EC 1.21.99.1

Orthology

K15393

beta-cyclopiazonate dehydrogenase

Genes

AOR:	AO090026000003

AFV:	AFLA_006317

Reference

1 [PMID:8076]

Authors

Edmondson DE, Kenney WC, Singer TP.

Title

Structural elucidation and properties of 8alpha-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and beta-cyclopiazonate oxidocyclase.

Journal

Biochemistry 15:2937-45 (1976)
DOI:10.1021/bi00659a001

Reference

2 [PMID:5143340]

Authors

Schabort JC, Potgeiter DJ.

Title

-cyclopiazonate oxidocyclase from Penicillium cyclopium. II. Studies on electron acceptors, inhibitors, enzyme kinetics, amino acid composition, flavin prosthetic group and other properties.

Journal

Biochim Biophys Acta 250:329-45 (1971)
DOI:10.1016/0005-2744(71)90189-6

Other DBs

ExplorEnz - The Enzyme Database:

1.21.99.1

IUBMB Enzyme Nomenclature:

1.21.99.1

ExPASy - ENZYME nomenclature database:

1.21.99.1

BRENDA, the Enzyme Database:

1.21.99.1

CAS:

9059-00-1

LinkDB

DBGET integrated database retrieval system