Entry
Name
2-epi-5-epi-valiolone dehydrogenase;
gadusol synthase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-epi-5-epi-valiolone:NAD+ 2,3-oxidoreductase
Reaction(IUBMB)
2-epi-5-epi-valiolone + NAD+ = demethylgadusol + NADH + H+ [RN:
R13233 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC
2.1.1.391 , demethylgadusol O-methyltransferase.
History
EC 1.3.1.126 created 2023
Orthology
K27180 2-epi-5-epi-valiolone dehydrogenase / demethylgadusol O-methyltransferase
Genes
XLA : 100158280(MGC147226.S)
SANH : 107666963 107680730
CAUA : 113050481 113096077
CGIB : 127960178 128015849
PTET : 122347014(zgc:113054)
MASI : 127445878 127449111
PSWI : 130208772(zgc:113054)
» show all
Taxonomy
Reference
Authors
Osborn AR, Almabruk KH, Holzwarth G, Asamizu S, LaDu J, Kean KM, Karplus PA, Tanguay RL, Bakalinsky AT, Mahmud T.
Title
De novo synthesis of a sunscreen compound in vertebrates.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.3.1.126
LinkDB
All DBs