KEGG   ENZYME: 1.3.1.96
Entry
EC 1.3.1.96                 Enzyme                                 
Name
Botryococcus squalene synthase;
SSL-2 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
squalene:NADP+ oxidoreductase
Reaction(IUBMB)
squalene + diphosphate + NADP+ = presqualene diphosphate + NADPH + H+ [RN:R02872]
Reaction(KEGG)
R02872
Substrate
squalene [CPD:C00751];
diphosphate [CPD:C00013];
NADP+ [CPD:C00006]
Product
presqualene diphosphate [CPD:C03428];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. cf. EC 2.5.1.21, squalene synthase, where squalene is formed directly from farnesyl diphosphate.
History
EC 1.3.1.96 created 2012
Orthology
K21149  botryococcus squalene synthase
Reference
1  [PMID:21746901]
  Authors
Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J
  Title
Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii.
  Journal
Proc Natl Acad Sci U S A 108:12260-5 (2011)
DOI:10.1073/pnas.1106222108
  Sequence
[ag:AEL16716]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.96
IUBMB Enzyme Nomenclature: 1.3.1.96
ExPASy - ENZYME nomenclature database: 1.3.1.96
BRENDA, the Enzyme Database: 1.3.1.96
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