KEGG   ENZYME: 1.8.1.20
Entry
EC 1.8.1.20                 Enzyme                                 
Name
4,4'-dithiodibutanoate disulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-sulfanylbutanoate:NAD+ oxidoreductase
Reaction(IUBMB)
2 4-sulfanylbutanoate + NAD+ = 4,4'-disulfanediyldibutanoate + NADH + H+ [RN:R11876]
Reaction(KEGG)
R11876
Substrate
4-sulfanylbutanoate [CPD:C21736];
NAD+ [CPD:C00003]
Product
4,4'-disulfanediyldibutanoate [CPD:C21737];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Rhodococcus erythropolis MI2, contains an FMN cofator.
History
EC 1.8.1.20 created 2017
Orthology
K22347  4,4'-dithiodibutanoate disulfide reductase
Genes
MIT: OCO_00550
MIA: OCU_00560
MID: MIP_00074
MYO: OEM_00550
MCHI: AN480_00300
MIR: OCQ_00550
MMAL: CKJ54_00265
MMM: W7S_00270
MYE: AB431_25170
MKU: I2456_00375
MADI: A7U43_07140
MNE: D174_24100
MYN: MyAD_23640
MFT: XA26_09370
MRH: MycrhN_2327
MAUU: NCTC10437_01289
MALV: MALV_43100
MPSC: MPSYJ_51650
MARZ: MARA_41720
MRF: MJO55_06525
RHA: RHA1_ro03649
RER: RER_60190
REY: O5Y_28900
REB: XU06_29215
RQI: C1M55_30700
ROP: ROP_34690
ROA: Pd630_LPD08040
RPY: Y013_16435
RBY: CEJ39_02880
RAV: AAT18_26630
RHW: BFN03_18040
RRZ: CS378_16005
RHQ: IM25_06325
RHOD: AOT96_10340
RRT: 4535765_00001
RCR: NCTC10994_02629
RKO: JWS14_19735(nox)
RGO: KYT97_19400(nox)
ROZ: CBI38_30455
RPSK: JWS13_25170(nox)
RGOR: NMQ04_20905
IAM: HC251_06655
IMA: PO878_06930
DHI: LH044_18490
 » show all
Reference
1  [PMID:26407888]
  Authors
Khairy H, Wubbeler JH, Steinbuchel A
  Title
Biodegradation of the organic disulfide 4,4'-dithiodibutyric acid by Rhodococcus spp.
  Journal
Appl Environ Microbiol 81:8294-306 (2015)
DOI:10.1128/AEM.02059-15
  Sequence
[rer:RER_60190]
Reference
2  [PMID:27564089]
  Authors
Khairy H, Wubbeler JH, Steinbuchel A
  Title
The NADH:flavin oxidoreductase Nox from Rhodococcus erythropolis MI2 is the key enzyme of 4,4'-dithiodibutyric acid degradation.
  Journal
Lett Appl Microbiol 63:434-441 (2016)
DOI:10.1111/lam.12662
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.20
IUBMB Enzyme Nomenclature: 1.8.1.20
ExPASy - ENZYME nomenclature database: 1.8.1.20
BRENDA, the Enzyme Database: 1.8.1.20
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