Entry |
|
Name |
3-hydroxymethylcephem carbamoyltransferase
|
Class |
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
|
Sysname |
carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase
|
Reaction(IUBMB) |
carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate = phosphate + a 3-carbamoyloxymethylcephem [RN: R04281]
|
Reaction(KEGG) |
|
Substrate |
carbamoyl phosphate [CPD: C00169];
3-hydroxymethylceph-3-em-4-carboxylate
|
Product |
phosphate [CPD: C00009];
3-carbamoyloxymethylcephem [CPD: C03674]
|
Comment |
Acts on a wide range of 3-hydroxymethylcephems (a subclass of the cephalosporin antibiotics). Activated by ATP.
|
History |
EC 2.1.3.7 created 1983
|
Pathway |
ec00311 | Penicillin and cephalosporin biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K04128 | hydroxymethyl cephem carbamoyltransferase |
|
Genes |
|
Reference |
|
Authors |
Brewer SJ, Taylor PM, Turner MK. |
Title |
An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.1.3.7 |
ExPASy - ENZYME nomenclature database: | 2.1.3.7 |
BRENDA, the Enzyme Database: | 2.1.3.7 |
|
LinkDB |
|