Entry
Name
acyl-homoserine-lactone synthase;
acyl-homoserine lactone synthase;
acyl homoserine lactone synthase;
acyl-homoserinelactone synthase;
acylhomoserine lactone synthase;
AHL synthase;
AHS;
AHSL synthase;
AhyI;
AinS;
AinS protein;
autoinducer synthase;
autoinducer synthesis protein rhlI;
EsaI;
ExpISCC1;
ExpISCC3065;
LasI;
LasR;
LuxI;
LuxI protein;
LuxM;
N-acyl homoserine lactone synthase;
RhlI;
YspI ;
acyl-[acyl carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-[acyl-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Reaction(IUBMB)
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone [RN:
R08940 ]
Reaction(KEGG)
Substrate
acyl-[acyl-carrier protein] [CPD:
C00173 ];
S-adenosyl-L-methionine [CPD:
C00019 ]
Product
[acyl-carrier protein] [CPD:
C00229 ];
S-methyl-5'-thioadenosine [CPD:
C00170 ];
N-acyl-L-homoserine lactone [CPD:
C18049 ]
Comment
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates [1]. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA [1]. S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone [1].
History
EC 2.3.1.184 created 2007
Pathway
ec00270 Cysteine and methionine metabolism
Orthology
K13060 acyl homoserine lactone synthase
K13061 acyl homoserine lactone synthase
K13062 acyl homoserine lactone synthase
K20248 acyl homoserine lactone synthase
K20249 acyl homoserine lactone synthase
K20250 acyl homoserine lactone synthase
K22954 acyl homoserine lactone synthase
K22955 acyl homoserine lactone synthase
K22956 acyl homoserine lactone synthase
K22957 acyl homoserine lactone synthase
K22968 acyl homoserine lactone synthase
Genes
CLAP : NCTC11466_01581(esaI)
YPE : YPO0984(yspI) YPO2456(ypeI)
YPK : y1733(ypeI) y3374(ytbI)
YPH : YPC_0811(yspI) YPC_1671(ypeI)
YPM : YP_2275(ypeI) YP_3455(yspI)
YPP : YPDSF_0534 YPDSF_1871
YPG : YpAngola_A0183(ytbI) YpAngola_A1716(ypsI)
YPZ : YPZ3_0754(ytbI) YPZ3_2106
YPT : A1122_00060 A1122_13865
YPD : YPD4_0709(ytbI) YPD4_2147
YPX : YPD8_0709(ytbI) YPD8_2240
YPW : CH59_4288(esaI) CH59_878(esaI)
YPJ : CH55_152(esaI) CH55_3555(esaI)
YPV : BZ15_1072(esaI) BZ15_2588(esaI)
YPL : CH46_2652(esaI) CH46_4160(esaI)
YPS : YPTB2499(ypsI) YPTB3258(yspI)
YPO : BZ17_3351(esaI) BZ17_4138(esaI)
YPI : YpsIP31758_0719(ytbI) YpsIP31758_1546(ypsI)
YPQ : DJ40_3178(esaI) DJ40_4043(esaI)
YPU : BZ21_1795(esaI) BZ21_2539(esaI)
YPR : BZ20_2855(esaI) BZ20_3710(esaI)
YPC : BZ23_2080(esaI) BZ23_2820(esaI)
YPF : BZ19_1861(esaI) BZ19_2665(esaI)
YEL : LC20_03387 LC20_06247 LC20_06258
YIN : CH53_2504(esaI) CH53_45(esaI)
YMA : DA391_13715 DA391_13770
YMO : HRD69_02710 HRD69_17490
YAS : N0H69_11685 N0H69_19260
SRY : M621_00125 M621_00360
SFJ : SAMEA4384070_0033(esaI_1) SAMEA4384070_0529(esaI_2)
SOF : NCTC11214_01456(lasI) NCTC11214_01474(esaI)
SFO : Z042_04915 Z042_25655
GQU : AWC35_07385 AWC35_11230
PROD : PCO85_05085 PCO85_05125
ETA : ETA_09530(expI) ETA_20810(phzI)
EBI : EbC_11190 EbC_15720(phzI)
ETP : LU633_05720 LU633_15180
ETO : RIN69_08635 RIN69_11875
EGE : EM595_1357 EM595_p0105(esaI)
PAM : PANA_1417 PANA_1955(eanI)
PLF : PANA5342_2226(eanI) PANA5342_2858(phzI)
PAJ : PAJ_0740 PAJ_1287(eanI)
PAQ : PAGR_g2152 PAGR_g2730
PVA : Pvag_0811(phzI) Pvag_pPag30142(pagI)
PAGG : AL522_00495 AL522_11335
PANP : PSNIH2_01590 PSNIH2_10680
PAGC : BEE12_09680 BEE12_13825
PSTW : DSJ_10310 DSJ_13985
PALH : B1H58_10825 B1H58_20100
PALF : K6R05_11955 K6R05_19455
PGZ : C2E15_07990 C2E15_17485
PCD : C2E16_07895 C2E16_17485
MINT : C7M51_00820(anoI) C7M51_02681(esaI)
MTHI : C7M52_00173(esaI) C7M52_01936(anoI)
MHAN : K6958_08185 K6958_17065
ANS : ArsFIN_07920(esaI_1) ArsFIN_37250(esaI_2)
LRI : NCTC12151_01600(lasI)
LAG : N175_15970 N175_16145
VAU : VANGNB10_cII0822(vanM) VANGNB10_cII0862c(vanI)
VFI : VF_1037(ainS) VF_A0924(luxI)
VFM : VFMJ11_1119 VFMJ11_A1042
VSA : VSAL_I1158(ainS) VSAL_II0957(luxI)
PAE : PA1432(lasI) PA3476(rhlI)
PAEV : N297_1473(lasI) N297_3599
PAEI : N296_1473(lasI) N296_3599
PAU : PA14_19130(rhlI) PA14_45940(lasI)
PAP : PSPA7_1650(rhlL) PSPA7_3897(lasI)
PAG : PLES_15361(rhlI) PLES_39821(lasI)
PAF : PAM18_1489(rhlI) PAM18_3699(lasI)
PNC : NCGM2_2314(lasI) NCGM2_4616(rhlI)
PAEB : NCGM1900_2792(rhlI) NCGM1900_5154(lasI)
PDK : PADK2_06880 PADK2_18565
PSG : G655_07335 G655_18055
PRP : M062_07680 M062_18540
PAEM : U769_07410 U769_18600
PAEL : T223_07650 T223_20340
PAES : SCV20265_1566 SCV20265_3992
PAEU : BN889_01520(lasI) BN889_03861(rhlL)
PAEG : AI22_14715 AI22_25965
PAEC : M802_1470(lasI) M802_3598
PAEO : M801_1472(lasI) M801_3464
PPAA : B7D75_07650 B7D75_17755
PFN : HZ99_01160 HZ99_23355
POI : BOP93_12330 BOP93_20445
PMUD : NCTC8068_02759(rhlI)
PBC : CD58_05210 CD58_16045
PCH : EY04_12065 EY04_26260
PCZ : PCL1606_11640 PCL1606_35600
PCP : JM49_05485 JM49_05810 JM49_17800
PSEM : TO66_12875 TO66_25920
PVK : EPZ47_16230 EPZ47_17255
PSEP : C4K39_1927 C4K39_3103
PPII : QL104_15665 QL104_25490
PANH : HU763_022785 HU763_024520
PCUC : PSH97_03900 PSH97_21430
CDIZ : CEDIAZO_01466(luxM)
CHAE : CH06BL_04480 CH06BL_45350
CARI : FNU76_03440 FNU76_05245 FNU76_06155
CKS : H9L41_18645 H9L41_22915
RSO : RSc3286(solI) RSp0779
RSE : F504_3331 F504_4445(rhiL)
RPU : CDC45_16810 CDC45_21505
RNC : GO999_00830 GO999_17925
RSL : RPSI07_0160(solI) RPSI07_mp0704(solI)
RSM : CMR15_10180(solI) CMR15_mp10744(solI)
BML : BMA10229_0609(bpsI) BMA10229_2020(bpmI)
BMN : BMA10247_A0700(bpmI) BMA10247_A0960(bpsI)
BMAL : DM55_4175 DM55_4903
BMAQ : DM76_3857 DM76_4875
BMAI : DM57_08085 DM57_10320
BMAF : DM51_3278 DM51_5000
BMAZ : BM44_4139 BM44_5033
BMAB : BM45_3261 BM45_3933
BPS : BPSS0885(pmlI) BPSS1180 BPSS1570
BPM : BURPS1710b_A0145(bviI) BURPS1710b_A0618(cepI) BURPS1710b_A2483(pmlI)
BPL : BURPS1106A_A1221(bpsI) BURPS1106A_A1577 BURPS1106A_A2129(bpmI)
BPD : BURPS668_A1293(bpsI) BURPS668_A1658 BURPS668_A2216(bpmI)
BPSE : BDL_4173 BDL_4467 BDL_4919
BPSM : BBQ_4578 BBQ_4988 BBQ_5252
BPSU : BBN_4344 BBN_4608 BBN_5016
BPSD : BBX_3632 BBX_4080 BBX_6013
BPZ : BP1026B_II0971(pmlI) BP1026B_II1251 BP1026B_II1673
BPQ : BPC006_II1237 BPC006_II1574 BPC006_II2109
BPK : BBK_3553 BBK_4222 BBK_5930
BPSH : DR55_3705 DR55_4147 DR55_4451
BPSA : BBU_4463 BBU_4881 BBU_5146
BPSO : X996_3489 X996_4121 X996_4384
BUT : X994_5545 X994_5975 X994_6240
BTE : BTH_II0804 BTH_II1227 BTH_II1512
BTQ : BTQ_4090 BTQ_4512 BTQ_4799
BTJ : BTJ_3431 BTJ_5122 BTJ_5495
BTZ : BTL_3594 BTL_3957 BTL_4279
BTV : BTHA_3678 BTHA_3920 BTHA_4294
BTHE : BTN_3412 BTN_3705 BTN_5576
BTHM : BTRA_3584 BTRA_4163 BTRA_4404
BTHA : DR62_3485 DR62_3739 DR62_5758
BTHL : BG87_3546 BG87_3969 BG87_4255
BUU : WS70_21840 WS70_25095
BSAV : WS86_23175 WS86_26740
BHG : I6G56_01105 I6G56_20145 I6G56_23555(bspI1)
BUD : AQ610_19425 AQ610_22930 AQ610_26240
BVI : Bcep1808_4001 Bcep1808_5262 Bcep1808_5752
BVE : AK36_3637 AK36_4698 AK36_5242
BCM : Bcenmc03_4280 Bcenmc03_5574
BCJ : BCAM0239a(cciI) BCAM1870(cepI)
BAC : BamMC406_4583 BamMC406_5823
BMK : DM80_4757(lasI) DM80_5277
BDL : AK34_3747(lasI) AK34_3771
BSTG : WT74_20005 WT74_28710
BGD : bgla_1p1740 bgla_2g11050
BUL : BW21_5391 BW21_6057 BW21_6274
BGP : BGL_1c07910(bpsI) BGL_2c03980(lasI) BGL_2c09850(rhL)
BPLA : bpln_1g07720 bpln_2g04430 bpln_2g10770
BURK : DM992_30915 DM992_35965
BXB : DR64_5938(lasI) DR64_8028
BPY : Bphyt_0126 Bphyt_4275
BUZ : AYM40_23345 AYM40_24680
PTS : CUJ90_21470 CUJ90_22005
PTRO : G5S35_16335 G5S35_31235
PDIO : PDMSB3_2770.1(lasI)
CABA : SBC2_27660 SBC2_36290
TVL : FAZ95_32595 FAZ95_32635
TCAR : U0034_22105 U0034_22220
PBH : AAW51_0117 AAW51_0198
SNIV : SFSGTM_11810(solI_1) SFSGTM_32150(solI_2)
FPHO : SHINM1_002780(solI)
MAM : Mesau_00935 Mesau_05623
MERD : EB233_29255 EB233_30020
MMEI : LRP31_10960 LRP31_34695
CHEA : PVE73_15495 PVE73_26085
AMIS : Amn_11570 Amn_13220 Amn_pd00730
PMOB : HG718_10825 HG718_12780
PECT : BN1012_Phect2085 BN1012_Phect36
SMK : Sinme_1745 Sinme_5835
SMX : SM11_chr1560(sinI) SM11_pC1008(traI)
SMI : BN406_01572 BN406_04334(traI) BN406_06844(traI)
SMEL : SM2011_c00168(sinI)
SMER : DU99_10035 DU99_23000
SMD : Smed_1560 Smed_5375 Smed_6489
RHI : NGR_a04220(traI) NGR_c16900
SFD : USDA257_c41150(traI)
SAME : SAMCFNEI73_Ch2069(traI) SAMCFNEI73_pB0529(traI)
SINO : SS05631_a49690 SS05631_c18490
ESJ : SJ05684_a41360 SJ05684_c17460
EAK : EKH55_1681 EKH55_5883
EMX : FKV68_10595 FKV68_22630 FKV68_24680
ENU : PYH37_004221 PYH37_006411(traI)
EGI : PZN02_003265 PZN02_006167(traI)
STEG : QA637_07790 QA637_25735(traI) QA637_30850
EAD : OV14_3020 OV14_c0101(traI)
ECAA : J3R84_08085 J3R84_37615 J3R84_38050
AGC : BSY240_350 BSY240_4768
ALF : CFBP5473_22130 CFBP5473_24970
ARUI : G6M88_22620 G6M88_24085 G6M88_25510(traI)
AVV : RvVAT039_30110(sinI) RvVAT039_pl07560(traI) RvVAT039_pl09450(traI)
AVF : RvVAR031_17530(sinI) RvVAR031_pl05510(traI)
ASAL : CFBP5507_24685 CFBP5507_27470(traI)
ACUC : KZ699_25435 KZ699_26325
ALEG : CFBP4996_26150 CFBP4996_27305
AVI : Avi_1889(avsI) Avi_8335(traI) Avi_9270(traI)
RET : RHE_CH02916(cinI) RHE_PA00179(traIa) RHE_PF00440(raiI)
REC : RHECIAT_CH0003073(cinI) RHECIAT_PC0000663(raiI)
REL : REMIM1_CH02968(raiI-1) REMIM1_PC00262(traI) REMIM1_PF00437(raiI-2)
REP : IE4803_CH03150(raiI-1) IE4803_PB00505 IE4803_PC00490(raiI-2)
REI : IE4771_CH03188(raiI-1) IE4771_PA00226(traI-1) IE4771_PB00397(traI-2) IE4771_PD00500(raiI-2)
RLE : RL3378(raiI) pRL70091(traIp7)
RLB : RLEG3_02880 RLEG3_25240
RLU : RLEG12_00075 RLEG12_10470 RLEG12_24445
RTR : RTCIAT899_PA01110(traIa) RTCIAT899_PB02960(traIb)
RGA : RGR602_CH03096(traI-1) RGR602_PA00197(traI-2) RGR602_PB00514(traI-3)
RHN : AMJ98_CH03088(raiI-1) AMJ98_PE00518(raiI-2)
RPHA : AMC79_CH03088(raiI-1) AMC79_PD00656(raiI-2)
RHK : Kim5_CH03137(raiI-1) Kim5_PC00448(raiI-2)
REZ : AMJ99_CH03087(raiI-1) AMJ99_PD00518(raiI-2)
RJG : CCGE525_32000 CCGE525_36820
RAD : CO657_13550 CO657_27805
RHID : FFM81_006550 FFM81_024975
RBQ : J2J99_15370 J2J99_30165 J2J99_30635 J2J99_31245 J2J99_32255
RLN : J0663_02125 J0663_23995 J0663_30110
RBAN : J2J98_14740 J2J98_22825 J2J98_27230
RRG : J3P73_17270 J3P73_25170 J3P73_34950
RLS : HB780_00710 HB780_09065 HB780_13300
RROS : D4A92_18535 D4A92_22430 D4A92_24745
RAW : NE851_07850(traI) NE851_26350 NE851_33445
RSUL : N2599_36425(traI) N2599_37560(traI)
RLW : RlegWSM1455_14745 RlegWSM1455_25875
ARA : Arad_14182(traI) Arad_8456(traIa)
RBW : RLCC275e_14825 RLCC275e_33690 RLCC275e_34380
NGL : RG1141_PB01730(traI)
NEN : NCHU2750_55770(traI) NCHU2750_59450(traI)
RFV : RFYW14_04144 RFYW14_04521
SHZ : shn_30465 shn_33220 shn_33715 shn_34470
BBT : BBta_5196 BBta_p0259(traI)
BRK : CWS35_28820 CWS35_32080
BGQ : X265_06165 X265_13355 X265_36350
BARH : WN72_33600 WN72_44480
BSEP : HAP48_0000025 HAP48_0001175
BQB : J4P68_0013705 J4P68_0041080
BBAN : J4G43_053780 J4G43_054860
BBRA : QA636_15710 QA636_35355
BXN : I3J27_34500 I3J27_35130
OCG : OCA5_pHCG301280(traI)
OCO : OCA4_pHCG3B01270(traI)
APOL : K9D25_21695(traI) K9D25_24595(traI)
CDQ : BOQ54_03250 BOQ54_04505
HDT : HYPDE_27393 HYPDE_40418
RLI : RLO149_c030680 RLO149_c036210 RLO149_c036590
DSH : Dshi_0312(luxI) Dshi_2851 Dshi_4152
PHP : PhaeoP97_02967(raiI)
PPIC : PhaeoP14_00306(raiI)
OCT : FTO60_01855 FTO60_13685
LEJ : ETW24_04260 ETW24_22620
SPSE : SULPSESMR1_00412(lasI)
RID : RIdsm_00061(lasI_1) RIdsm_00113(lasI_2)
ROM : EI983_02570 EI983_03040
AHT : ANTHELSMS3_02147(bjaI)
OCD : FHY55_02580 FHY55_05970 FHY55_12695
ROT : FIV09_01495(lasI) FIV09_13055(bjaI)
LALG : LentiSH36_00627(raiI)
TRY : QF118_02980 QF118_18575
PGV : SL003B_0643 SL003B_0702 SL003B_p0045
SECH : B18_00435 B18_18930
APER : A0U91_00230 A0U91_10770
AOT : AcetOri_orf01265 AcetOri_orf04004
SKT : IGS68_20745 IGS68_34240
» show all
Taxonomy
Reference
Authors
Schaefer AL, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP
Title
Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein.
Journal
Reference
Authors
Watson WT, Murphy FV 4th, Gould TA, Jambeck P, Val DL, Cronan JE Jr, Beck von Bodman S, Churchill ME.
Title
Crystallization and rhenium MAD phasing of the acyl-homoserinelactone synthase EsaI.
Journal
Reference
Authors
Chakrabarti S, Sowdhamini R.
Title
Functional sites and evolutionary connections of acylhomoserine lactone synthases.
Journal
Reference
Authors
Hanzelka BL, Parsek MR, Val DL, Dunlap PV, Cronan JE Jr, Greenberg EP
Title
Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein.
Journal
Reference
Authors
Parsek MR, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP.
Title
Acyl homoserine-lactone quorum-sensing signal generation.
Journal
Sequence
Reference
Authors
Ulrich RL.
Title
Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis.
Journal
Reference
Authors
Gould TA, Schweizer HP, Churchill ME
Title
Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI.
Journal
Reference
Authors
Raychaudhuri A, Jerga A, Tipton PA
Title
Chemical mechanism and substrate specificity of RhlI, an acylhomoserine lactone synthase from Pseudomonas aeruginosa.
Journal
Reference
Authors
Gould TA, Herman J, Krank J, Murphy RC, Churchill ME.
Title
Specificity of acyl-homoserine lactone synthases examined by mass spectrometry.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.184
LinkDB
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