Entry Name 3,5,7-trioxododecanoyl-CoA synthase;
Class Transferases;BRITE hierarchy
Sysname malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming)
Reaction(IUBMB) 3 malonyl-CoA + hexanoyl-CoA = 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 [RN:
R10171 ]
Reaction(KEGG) Substrate Product Comment A polyketide synthase catalysing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalysed by EC
4.4.1.26 , olivetolic acid cyclase.
History EC 2.3.1.206 created 2012
Pathway ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
Orthology K20503 3,5,7-trioxododecanoyl-CoA synthase
Genes CSAV : 115699293 115700696
Taxonomy Reference Authors Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S
Title Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway.
Journal Sequence Reference Authors Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE
Title Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.3.1.206
LinkDB All DBs
