| Entry |
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| Name |
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
TDP-fucosamine acetyltransferase;
WecD;
RffC
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-CoA:dTDP-4-amino-4,6-dideoxy-alpha-D-galactose N-acetyltransferase
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| Reaction(IUBMB) |
acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose [RN: R10142]
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| Reaction(KEGG) |
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| Substrate |
acetyl-CoA [CPD: C00024];
dTDP-4-amino-4,6-dideoxy-alpha-D-galactose [CPD: C04346]
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| Product |
CoA [CPD: C00010];
dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose [CPD: C20415]
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| Comment |
The product, TDP-4-acetamido-4,6-dideoxy-D-galactose, is utilized in the biosynthesis of enterobacterial common antigen (ECA).
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| History |
EC 2.3.1.210 created 2012
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| Pathway |
| ec00541 | Biosynthesis of various nucleotide sugars |
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| Orthology |
| K16704 | dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase |
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| Genes |
| ECOO: | ECRM13514_4850(rffC) |
| ECOH: | ECRM13516_4635(rffC) |
| ECW: | EcE24377A_4301(wecD) |
| EDJ: | ECDH1ME8569_3672(rffC) |
| ENHK: | EnteroDNA1_02611(wecD) |
| REE: | electrica_04899(wecD) |
| METY: | MRY16398_54530(wecD) |
| MPHG: | MPHASIOC01_005254(rffC) |
| PSTS: | E05_20710 E05_20720 |
| YPG: | YpAngola_A0518(wecD) |
| YPI: | YpsIP31758_0188(wecD) |
| SMW: | SMWW4_v1c01770(rffC) |
| SSAR: | SSARUM_000128(rffC) |
| PAQU: | DMB82_0019225(wecD) |
| PARL: | PEC302110_01590(rffC) |
| DIC: | Dpoa569_0000282(rffC) |
| MINT: | C7M51_03212(wecD_2) |
| MTHI: | C7M52_03787(wecD_2) |
| ALIG: | NCTC10568_01905(rffC) |
| CAMU: | CA2015_3028 CA2015_3629 |
| BAZ: | BAMTA208_19180(spsD) |
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| Reference |
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| Authors |
Hung MN, Rangarajan E, Munger C, Nadeau G, Sulea T, Matte A |
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| Title |
Crystal structure of TDP-fucosamine acetyltransferase (WecD) from Escherichia coli, an enzyme required for enterobacterial common antigen synthesis. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.210 |
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| LinkDB |
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