KEGG   ENZYME: 2.3.1.310
Entry
EC 2.3.1.310                Enzyme                                 
Name
benzoylsuccinyl-CoA thiolase;
bbsAB (gene names)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
(S)-2-benzoylsuccinyl-CoA:CoA benzoyltransferase (benzoyl-CoA-forming)
Reaction(IUBMB)
(S)-2-benzoylsuccinyl-CoA + CoA = benzoyl-CoA + succinyl-CoA [RN:R05587]
Reaction(KEGG)
R05587
Substrate
(S)-2-benzoylsuccinyl-CoA [CPD:C09820];
CoA [CPD:C00010]
Product
benzoyl-CoA [CPD:C00512];
succinyl-CoA [CPD:C00091]
Comment
The enzyme, characterized from the bacteria Thauera aromatica and Geobacter metallireducens, participates in an anaerobic toluene degradation pathway.
History
EC 2.3.1.310 created 2022
Pathway
ec00623  Toluene degradation
Orthology
K07549  benzoylsuccinyl-CoA thiolase BbsA subunit
K07550  benzoylsuccinyl-CoA thiolase BbsB subunit
Genes
EBA: c2A315(bbsB) c2A316(bbsA)
APET: ToN1_01600(bbsB) ToN1_01610(bbsA)
AZI: AzCIB_4525 AzCIB_4526
AZD: CDA09_07420 CDA09_07425 CDA09_21990 CDA09_21995
TCL: Tchl_1385 Tchl_1386
TAK: Tharo_3089 Tharo_3090
BGEA: ACP2YP_00665
GME: Gmet_1528(bbsA) Gmet_1529(bbsB)
GEO: Geob_2427(bbsA) Geob_2428(bbsB)
DTO: TOL2_C01440(bbsB2) TOL2_C01480(bbsB) TOL2_C04900(bhsA) TOL2_C04910(bhsB)
DOV: DSCO28_00270 DSCO28_65750 DSCO28_65760
DWD: DSCW_52910 DSCW_52920
DVR: Dvar_31580 Dvar_31590 Dvar_48730 Dvar_48740
DMM: dnm_089750(bhsA) dnm_089760(bhsB)
MZL: GKS04_01190
DGI: Desgi_0641
HDO: MUK72_17285
 » show all
Reference
1  [PMID:10629170]
  Authors
Leuthner B, Heider J
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000
  Sequence
[ag:AAF89836 AAF89837]
Reference
2  [PMID:35313080]
  Authors
Weidenweber S, Schuhle K, Lippert ML, Mock J, Seubert A, Demmer U, Ermler U, Heider J.
  Title
Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.
  Journal
FEBS J 289:5599-5616 (2022)
DOI:10.1111/febs.16443
  Sequence
[gme:Gmet_1528 Gmet_1529]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.310
IUBMB Enzyme Nomenclature: 2.3.1.310
ExPASy - ENZYME nomenclature database: 2.3.1.310
BRENDA, the Enzyme Database: 2.3.1.310
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