Entry
Name
glycoprotein 3-alpha-L-fucosyltransferase;
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase;
GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase;
GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase;
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] 3-alpha-L-fucosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-beta-L-fucose + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein] [RN:
R06015 ]
Reaction(KEGG)
Substrate
GDP-beta-L-fucose [CPD:
C00325 ];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]
Product
GDP [CPD:
C00035 ];
N4-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc}-L-asparaginyl-[protein]
Comment
Requires Mn2+. The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. This enzyme catalyses a reaction similar to that of EC
2.4.1.68 , glycoprotein 6-alpha-L-fucosyltransferase, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha1,3-linkage rather than an alpha1,6-linkage. The {iupac/misc/glycp#3.5::N-glycan} products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).
History
EC 2.4.1.214 created 2001
Pathway
ec00513 Various types of N-glycan biosynthesis
Orthology
K00753 glycoprotein 3-alpha-L-fucosyltransferase
Genes
BFO : 118405950 118406257 118411908 118412045 118412254 118412440 118413693 118425677 118426531 118426592 118426593 118429660 118430705 118432514 118432653
BBEL : 109461731 109462467 109466362 109467558 109467559 109468794 109470793 109472650 109473253 109485218
SCLV : 120326252 120326253 120326461 120327132 120330128 120332423 120335441 120335442 120336318 120343945
SPU : 100892875 105437757 105440751 105445519 115922761 115925446 115925447 115925451 115925452 115926808 574917 579774 582389 588755 753114
APLC : 110976930 110978134 110981755 110989340 110990202
DSI : Dsimw501_GD14528(Dsim_GD14528)
DPO : 4813686 6903001 6903002
DPE : 113565816 6588690 6596938
DMN : 108151409 108162167 108162168
CCAT : 101458318 101459389
AALI : 118457839 118466696
CNS : 116338840 116341884 116342793 116346121 116351383
BCOO : 119074458 119074986 119074987
AGIF : 122854943 122855072
PPYR : 116171534 116171751
CFEL : 113378576 113378623
API : 100161726 100163995 100165601 100167629 100168794 100574117
DNX : 107162725 107172392 107173073 107173609
AGS : 114123584 114128008 114128010 114128011
RMD : 113548005 113548044 113558478 113560434 113560693
ACOO : 126839152 126843891 126846437 126847141
NLU : 111049328 111052441 111055726 111059937 111060313 120355815 120356429
MQU : 128983214 128991746 128991881
SGRE : 126297701 126336388
FCD : 110843011 110843249 110844424 110849065 110850423 110852611 110852612 110852710
PPOI : 119092228 119111175 119113694
DSV : 119434812 119448844 119450320 119450510 119450512
RSAN : 119381841 119381842 119383418 119383601 119390909
RMP : 119169683 119169686 119169687 119170382
CSCU : 111622473 111622475 111628209
PTEP : 107436083 107450737
ABRU : 129961845 129976072
PMEO : 129586113 129601335 129602741
CBR : CBG_19588(Cbr-fut-4)
TSP : Tsp_00082 Tsp_02347a Tsp_02348
HRO : HELRODRAFT_123182 HELRODRAFT_166201 HELRODRAFT_84937 HELRODRAFT_86301
LGI : LOTGIDRAFT_129140 LOTGIDRAFT_152652
PVUL : 126819755 126823520 126826665 130010439
PCAN : 112555025 112555027 112556484 112560468
GAE : 121378023 121378119 121380440
HRF : 124114396 124119078 124119416 124119753 124121687 124124454 124126776 124130905 124130907 124137964 124140233 124140289 124143524 124146870
HRJ : 124252815 124252818 124260813 124268700 124281133 124285760 124287142
CRG : 105319931 105326742 105340008 117683259
CVN : 111099650 111119322 111120726 111128839 111131869 111132349
CANU : 128156734 128157783 128158192 128175064 128180793 128187100
OED : 125645608 125645960 125652629 125658230 125666024 125674931 125676000 130052739
MYI : 110443530 110450259 110456621 110456628 110456630 110456631 110459974 110464928
PMAX : 117316783 117317092 117326151 117326152 117336016 117342927
MCAF : 127704276 127721169 127737403
MMER : 123528191 123535574 123535747 123535763 123559052 123562846 123565607
RPHI : 132713414 132713415 132722286 132734468 132739405 132741176 132742295 132754225 132758211 132759992
DPOL : 127831519 127831529 127831557 127833669 127833670 127835094
OBI : 106876232 106876522 106882619
OSN : 115211825 115226009 115226011 115226504 115226505 115226509 115227328 115230711 115230712 118768515
LAK : 106150569 106150572 106156269 106159224 106160406 106163945 106166124 106166131 106171537 106172205 106172987 106174364 106176482 112042190
SMM : Smp_054300 Smp_129750 Smp_154410 Smp_211180
SHX : MS3_00004047(FUT9_3) MS3_00008027(FUT9_7)
PDAM : 113665367 113676257 113676359
SPIS : 111323780 111330794
HSY : 130648466 130653587 130656526
TAD : TRIADDRAFT_20532 TRIADDRAFT_3614
ATH : AT1G49710(FUT12) AT3G19280(FUT11)
CSAT : 104742504 104746313 104758303 104765792 104777890
EUS : EUTSA_v10011402mg EUTSA_v10022257mg
BRP : 103832922 103869473 103871397
BNA : 106346129 106406562 106418732 106428330 106439064 111204765 125608922
BOE : 106301123 106307787 106343405
RSZ : 108813729 108823121 108857666
GRA : 105762819 105773248 105782696
GHI : 107894268 107928817 107934110 107937965 107953397
GAB : 108462114 108476746 108482200 108485473
HSYR : 120120811 120122112 120123950 120128066 120187446
LJA : Lj4g3v0598850.1(Lj4g3v0598850.1)
LANG : 109331404 109333305 109349444
PCIN : 129285184 129293892 129299700
QSA : O6P43_011719 O6P43_031030
MSYL : 126584694 126622413
CSAV : 115702925 115702932
MCHA : 111007907 111017732
CMAX : 111470944 111482907
CMOS : 111430616 111455575
CPEP : 111810161 111811265
SPEN : 107002790 107004595
SSTN : 125844254 125864857
SDUL : 129876229 129885557
CANN : 107840277 107855995
NTA : 107766938 107767349(FucT) 107797347 107830046
INI : 109154539 109161366 109165387
ITR : 116028671 116028672 116030067 116032462
SIND : 105169541 105172719
OEU : 111389108 111410807 111412885
SSPL : 121753942 121757044 121809982
SHIS : 125217672 125220206
LSV : 111877656 111880602 111895636
CCAV : 112500611 112507506
DCR : 108201987 108222779 108225732
AEW : 130755295 130774113 130778910 130781010
MING : 122060511 122079687
PSOM : 113289512 113297777
DOSA : Os08t0472600-01(Os08g0472600)
TAES : 123154940 123156180 543033
PVIR : 120678853 120712625
MUS : 103968374 103968680 103977535
ZOF : 121982372 121986259 121992991 121996985
DCT : 110092524 110100572 110113811
MSIN : 131236404 131242490
SMO : SELMODRAFT_452935(FucTA)
SMIN : v1.2.020659.t1(symbB.v1.2.020659.t1)
» show all
Taxonomy
Reference
Authors
Wilson IB, Rendic D, Freilinger A, Dumic J, Altmann F, Mucha J, Muller S, Hauser MT.
Title
Cloning and expression of cDNAs encoding alpha1,3-fucosyltransferase homologues from Arabidopsis thaliana.
Journal
Sequence
Reference
Authors
Fabini G, Freilinger A, Altmann F, Wilson IB
Title
Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseadish peroxidase epitope.
Journal
Sequence
Reference
Authors
Leiter H, Mucha J, Staudacher E, Grimm R, Glossl J, Altmann F.
Title
Purification, cDNA cloning, and expression of GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase from mung beans.
Journal
Sequence
Reference
Authors
van Tetering A, Schiphorst WE, van den Eijnden DH, van Die I.
Title
Characterization of a core alpha1-->3-fucosyltransferase from the snail Lymnaea stagnalis that is involved in the synthesis of complex-type N-glycans.
Journal
Reference
Authors
Staudacher E, Altmann F, Glossl J, Marz L, Schachter H, Kamerling JP, Hard K, Vliegenthart JF.
Title
GDP-fucose: beta-N-acetylglucosamine (Fuc to (Fuc alpha 1----6GlcNAc)-Asn-peptide)alpha 1----3-fucosyltransferase activity in honeybee (Apis mellifica) venom glands. The difucosylation of asparagine-bound N-acetylglucosamine.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.214
LinkDB
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