| Entry |
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| Name |
erythronolide mycarosyltransferase;
EryBV
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
dTDP-beta-L-mycarose:erythronolide B L-mycarosyltransferase
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| Reaction(IUBMB) |
dTDP-beta-L-mycarose + erythronolide B = dTDP + 3-alpha-L-mycarosylerythronolide B [RN: R05530]
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| Reaction(KEGG) |
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| Substrate |
dTDP-beta-L-mycarose [CPD: C11916];
erythronolide B [CPD: C06635]
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| Product |
dTDP [CPD: C00363];
3-alpha-L-mycarosylerythronolide B [CPD: C06630]
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| Comment |
Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin.
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| History |
EC 2.4.1.328 created 2014
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| Pathway |
| ec00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K14367 | erythronolide mycarosyltransferase |
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| Genes |
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| Reference |
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| Authors |
Zhang C, Fu Q, Albermann C, Li L, Thorson JS |
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| Title |
The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.328 |
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| LinkDB |
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