Entry
Name
CDP-abequose:alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und alpha-1,3-abequosyltransferase;
wbaV (gene name);
rfbV (gene name);
trihexose diphospholipid abequosyltransferase;
abequosyltransferase (ambiguous);
CDP-alpha-D-abequose:Man(alpha1->4)Rha(alpha1->3)Gal(beta-1)-diphospholipid D-abequosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
CDP-alpha-D-abequose:alpha-D-mannopyranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 3III-alpha-abequosyltransferase (configuration retaining)
Reaction(IUBMB)
CDP-alpha-D-abequose + alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und = CDP + alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und [RN:
R04581 ]
Reaction(KEGG)
Substrate
CDP-alpha-D-abequose [CPD:
C01788 ];
alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und [CPD:
C04724 ]
Product
CDP [CPD:
C00112 ];
alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und [CPD:
C04808 ]
Comment
The enzyme from Salmonella participates in the biosynthesis of the repeat unit of O antigens produced by strains that belong to the A, B and D1-D3 groups. The enzyme is able to transfer abequose, paratose, or tyvelose, depending on the availability of the specific dideoxyhexose in a particular strain.
History
EC 2.4.1.60 created 1972, modified 2012, modified 2021
Orthology
K13005 O-antigen biosynthesis alpha-1,3-abequosyltransferase
Genes
SPT : SPA0780(rfbV) SPA0782(rfbV) SPA0784(rfbV)
GEF : FO488_01040 FO488_03040
» show all
Taxonomy
Reference
Authors
Osborn MJ, Weiner IM.
Title
Biosynthesis of a bacterial lipopolysaccharide. VI. Mechanism of incorporation of abequose into the O-antigen of Salmonella typhimurium.
Journal
J Biol Chem 243:2631-9 (1968)
Sequence
Reference
Authors
Liu D, Lindqvist L, Reeves PR
Title
Transferases of O-antigen biosynthesis in Salmonella enterica: dideoxyhexosyltransferases of groups B and C2 and acetyltransferase of group C2.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.60
ExPASy - ENZYME nomenclature database: 2.4.1.60
LinkDB
All DBs