Entry
Name
NAD+---diphthamide ADP-ribosyltransferase;
ADP-ribosyltransferase;
mono(ADPribosyl)transferase;
NAD---diphthamide ADP-ribosyltransferase;
NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
NAD+:diphthamide-[translation elongation factor 2] N-(ADP-D-ribosyl)transferase
Reaction(IUBMB)
NAD+ + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2] [RN:
R04074 ]
Reaction(KEGG)
Substrate
NAD+ [CPD:
C00003 ];
diphthamide-[translation elongation factor 2]
Product
nicotinamide [CPD:
C00153 ];
N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
Comment
Diphtheria toxin and some other bacterial toxins catalyse this reaction, which inactivates translation elongation factor 2 (EF2). The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC
2.4.2.31 NAD(P)+---protein-arginine ADP-ribosyltransferase. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii.
History
EC 2.4.2.36 created 1990, modified 2013
Orthology
K00776 NAD-diphthamide ADP-ribosyltransferase
K10928 cholera enterotoxin subunit A
Genes
ELH : ETEC_p666_0660(eltA)
ECW : EcE24377A_F0020(eltA)
VCO : VC0395_0512(ctxA) VC0395_A1060(ctxA)
VCR : VC395_1571(ctxA) VC395_A0747(ctxA)
CDW : CDPW8_0179(tox1) CDPW8_0220(tox2)
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Taxonomy
Reference
Authors
Lee H, Iglewski WJ.
Title
Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A.
Journal
Reference
Authors
Ueda K, Hayaishi O
Title
ADP-ribosylation.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.36
ExPASy - ENZYME nomenclature database: 2.4.2.36
LinkDB
All DBs