Entry
Name
4-hydroxyglutamate transaminase;
4-hydroxyglutamate aminotransferase;
4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
erythro-4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
erythro-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate [RN:
R05052 ]
Reaction(KEGG)
Substrate
erythro-4-hydroxy-L-glutamate [CPD:
C05947 ];
2-oxoglutarate [CPD:
C00026 ]
Product
(4R)-4-hydroxy-2-oxoglutarate [CPD:
C05946 ];
L-glutamate [CPD:
C00025 ]
Comment
The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC
2.6.1.1 aspartate transaminase.
History
EC 2.6.1.23 created 1972, modified 1982, modified 2020
Pathway
ec00330 Arginine and proline metabolism
Reference
Authors
GOLDSTONE A, ADAMS E.
Title
Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver.
Journal
J Biol Chem 237:3476-85 (1962)
Reference
Authors
KURATOMI K, FUKUNAGA K, KOBAYASHI Y.
Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. II. A TRANSAMINASE CONCERNED IN GAMMA-HYDROXYGLUTAMATE METABOLISM.
Journal
Reference
Authors
MAITRA U, DEEKKER E
Title
PURIFICATION OF RAT-LIVER GAMMA-HYDROXYGLUTAMATE TRANSAMINASE AND ITS PROBABLE IDENTITY WITH GLUTAMATE-ASPARTATE TRANSAMINASE.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.23
ExPASy - ENZYME nomenclature database: 2.6.1.23
LinkDB
All DBs