Entry
Name
teichoic acid D-alanine hydrolase;
fmtA (gene name)
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
teichoic acid D-alanylhydrolase
Reaction(IUBMB)
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H2O = [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine [RN:
R11965 ]
Reaction(KEGG)
Substrate
[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan;
H2O [CPD:
C00001 ]
Product
[(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan;
D-alanine [CPD:
C00133 ]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, removes D-alanine groups from the teichoic acid produced by this organism, thus modulating the electrical charge of the bacterial surface. The activity greatly increases methicillin resistance in MRSA strains.
History
EC 3.1.1.103 created 2018
Orthology
K22580 teichoic acid D-alanine hydrolase
Genes
BAZ : BAMTA208_08665(pbpX)
BSTR : QI003_09070 QI003_12495
BCR : BCAH187_A3518 BCAH187_A4174
BCQ : BCQ_3295(bla) BCQ_3833
BCER : BCK_14985 BCK_17770
BCEF : BcrFT9_02665 BcrFT9_03155
BTB : BMB171_C3163 BMB171_C3707 BMB171_P0160
BTHR : YBT1520_18415 YBT1520_21525
BTHI : BTK_18405 BTK_21375
BTF : YBT020_17115 YBT020_19905
BTHY : AQ980_09635 AQ980_12640
BWE : BcerKBAB4_3210 BcerKBAB4_3872
BMYO : BG05_1979 BG05_2505
SAX : USA300HOU_1001(fmt1)
SUX : SAEMRSA15_08880(fmt)
SUF : SARLGA251_09710(fmt)
SAUV : SAI7S6_1007490(fmtA)
SAUW : SAI5S5_1007450(fmtA)
SAUX : SAI6T6_1007460(fmtA)
SAUY : SAI8T7_1007490(fmtA)
SDP : NCTC12225_02173(fmtA)
SSIF : AL483_06610 AL483_06615
SPIC : SAMEA4384060_1899(fmtA_2)
SSH : NCTC13712_01002(fmtA_1)
SSIM : SAMEA4384339_0968(fmtA_1)
SSTE : SAMEA4384403_1803(fmtA)
MARY : LAU42_03235 LAU42_03240
MCAK : MCCS_07670(pbpX_1) MCCS_07680(pbpX_2)
LMOC : LMOSLCC5850_0533(pbpX)
LMW : LMOSLCC2755_0545(pbpX)
LMX : LMOSLCC2372_0549(pbpX)
LMZ : LMOSLCC2482_0542(pbpX)
LMON : LMOSLCC2376_0519(pbpX)
LMOS : LMOSLCC7179_0515(pbpX)
LMOO : LMOSLCC2378_0564(pbpX)
LMOY : LMOSLCC2479_0547(pbpX)
LMOT : LMOSLCC2540_0545(pbpX)
LMOA : LMOATCC19117_0570(pbpX)
LGZ : NCTC10812_00946(fmtA_1) NCTC10812_01209(fmtA_2)
LJF : FI9785_1472(pbpX) FI9785_1730
LJN : T285_07215 T285_08775
LAC : LBA0059(pbpX) LBA0858 LBA1006 LBA1605(pbpX)
LAD : LA14_0059 LA14_0882 LA14_1021 LA14_1596
LAF : SD55_0058(pbpX1) SD55_0880 SD55_1021 SD55_1605(pbpX2)
LDE : LDBND_1553 LDBND_1554
LHE : lhv_0070 lhv_0912 lhv_1103 lhv_1192
LHL : LBHH_0081 LBHH_0974 LBHH_1106 LBHH_1247
LHR : R0052_00420 R0052_05750 R0052_06505 R0052_07365
LHV : lhe_0078 lhe_0876 lhe_1002 lhe_1083
LHH : LBH_0054 LBH_0761 LBH_0901
LHD : HUO_01315 HUO_06210 HUO_06715 HUO_07495
LCR : LCRIS_00057 LCRIS_00552(pbp1) LCRIS_00881 LCRIS_01083(pbpX)
LAI : LAC30SC_00255 LAC30SC_04310 LAC30SC_05065
LAY : LAB52_04290 LAB52_05025
LKE : WANG_0789 WANG_1631(pbpX)
LGL : AO203_02730 AO203_07280 AO203_08025 AO203_08705
LTA : H1A07_07225 H1A07_08850
LUU : H4B44_00405 H4B44_06810
LBN : LBUCD034_0131(pbpX1)
LPAR : FAM21731_00881 FAM21731_00888
WVR : IE337_04570 IE337_04585
» show all
Taxonomy
Reference
Authors
Komatsuzawa H, Sugai M, Ohta K, Fujiwara T, Nakashima S, Suzuki J, Lee CY, Suginaka H
Title
Cloning and characterization of the fmt gene which affects the methicillin resistance level and autolysis in the presence of triton X-100 in methicillin-resistant Staphylococcus aureus.
Journal
Sequence
Reference
Authors
Qamar A, Golemi-Kotra D
Title
Dual roles of FmtA in Staphylococcus aureus cell wall biosynthesis and autolysis.
Journal
Reference
Authors
Rahman MM, Hunter HN, Prova S, Verma V, Qamar A, Golemi-Kotra D
Title
The Staphylococcus aureus Methicillin Resistance Factor FmtA Is a d-Amino Esterase That Acts on Teichoic Acids.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.1.1.103
LinkDB
All DBs