| Entry |
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| Name |
type II site-specific deoxyribonuclease;
type II restriction enzyme
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| Class |
Hydrolases;
Acting on ester bonds;
Endodeoxyribonucleases producing 5'-phosphomonoesters
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| Reaction(IUBMB) |
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates
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| Comment |
This is a large group of enzymes which, together with those now listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease) and EC 3.1.21.5.
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| History |
EC 3.1.21.4 created 1984 from EC 3.1.23 and EC 3.1.24
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| Orthology |
| K01155 | type II restriction enzyme |
| K21512 | Enterobacteria phage terminase large subunit |
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| Genes |
| ECOC: | C3026_04135 C3026_04455 C3026_04775 |
| ECF: | ECH74115_1620 ECH74115_1783 |
| EOJ: | ECO26_0602 ECO26_1140 ECO26_1954 ECO26_2635 |
| ECOO: | ECRM13514_0554 ECRM13514_1822 |
| ECR: | ECIAI1_0782(A) ECIAI1_1588(A) |
| EUM: | ECUMN_0613 ECUMN_1416(A) |
| ECOB: | C3029_07670 C3029_07990 |
| PSYC: | DABAL43B_0175(dpnC) |
| NMQ: | NMBM04240196_1831(dpnC) |
| NMZ: | NMBNZ0533_0434(dpnC) |
| NCI: | NCTC10296_01548(drg) |
| RPF: | Rpic12D_5105 Rpic12D_5341 |
| ACK: | C380_05645 C380_06130 |
| ADK: | Alide2_2717 Alide2_3383 |
| DOE: | DENOEST_1706 DENOEST_1864 |
| BSTA: | ACETK8_01165 ACETK8_10895 |
| SCLO: | SCLO_2000340 SCLO_2000910 |
| HEO: | C694_00445 C694_01325 |
| HHP: | HPSH112_00440 HPSH112_01610 HPSH112_07165 |
| HHQ: | HPSH169_00435 HPSH169_01495 |
| HHR: | HPSH417_00435 HPSH417_01325 |
| HPP: | HPP12_0094 HPP12_0261 HPP12_1390 |
| HPI: | hp908_0275 hp908_1401 |
| HPQ: | hp2017_02682 hp2017_1355 |
| HPW: | hp2018_02712 hp2018_1358(ecoRIb) |
| HEF: | HPF16_0104 HPF16_0269 |
| HPF: | HPF30_1034 HPF30_1170 HPF30_1286 |
| HPT: | HPSAT_00425 HPSAT_01310 |
| HPN: | HPIN_00435 HPIN_01180 |
| HEU: | HPPN135_00465 HPPN135_01355 HPPN135_07160 |
| HES: | HPSA_00475 HPSA_01325 |
| HCN: | HPB14_00445 HPB14_01295 |
| HER: | C695_00445 C695_01320 |
| HEI: | C730_00445 C730_01325 |
| HPYA: | HPAKL117_01305 HPAKL117_06780 |
| HPYK: | HPAKL86_01620 HPAKL86_02540 |
| HPYO: | HPOK113_0103 HPOK113_0271 |
| HPYL: | HPOK310_0104 HPOK310_0266 |
| HPYU: | K751_06130 K751_07180 |
| HPYM: | K749_04345 K749_05095 |
| HEM: | K748_02765 K748_03515 |
| HEB: | U063_0255 U063_0435 U063_0602 |
| HEZ: | U064_0256 U064_0436 U064_0603 |
| HBI: | HBZC1_02930 HBZC1_18460 |
| TRI: | DYE50_05450 DYE50_05455 |
| MROB: | HH214_08975 HH214_21805 |
| RSI: | Runsl_4415 Runsl_5934 |
| HYP: | A0257_21060 A0257_21935 |
| RAN: | Riean_1467 Riean_1818 |
| SDB: | CNQ82_02135 CNQ82_02140 |
| GHA: | NCTC10459_00255(mboIR) |
| SST: | SSUST3_0037 SSUST3_0038 |
| SSUY: | YB51_0180 YB51_0185 |
| SSK: | SSUD12_0038 SSUD12_0039 |
| SSQ: | SSUD9_0036 SSUD9_0037 |
| SVB: | NCTC12167_00979(mboIR) |
| SFER: | NCTC12278_00538(mboIR) |
| PHX: | KGNDJEFE_00423(dpnB) |
| MCOU: | NCTC10179_00204(dpnB) |
| MFM: | MfeM64YM_0146(dpnII) |
| LEN: | LEP3755_46750 LEP3755_63490 |
| CALS: | NIES3974_00330(dpnB) |
| DCM: | NIES806_45140(avaIR) |
| MEAE: | QEN48_02780 QEN48_06530 |
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| Reference |
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| Authors |
Roberts RJ. |
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| Title |
Restriction enzymes and their isoschizomers. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.21.4 |
| ExPASy - ENZYME nomenclature database: | 3.1.21.4 |
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| LinkDB |
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