KEGG   ENZYME: 3.1.3.107
Entry
EC 3.1.3.107                Enzyme                                 
Name
amicoumacin phosphatase;
amiO (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
amicoumacin 2-phosphate phosphohydrolase
Reaction(IUBMB)
amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate [RN:R12531]
Reaction(KEGG)
R12531
Substrate
amicoumacin A 2-phosphate [CPD:C22232];
H2O [CPD:C00001]
Product
amicoumacin A [CPD:C22231];
phosphate [CPD:C00009]
Comment
This bacterial enzyme activates the antibiotic amicoumacin A by removing a phosphate group that is added by EC 2.7.1.230, amicoumacin kinase.
History
EC 3.1.3.107 created 2019
Orthology
K23984  amicoumacin phosphatase
Genes
BPU: BPUM_0641
BPUS: UP12_03560
BSAF: BSL056_03375
BJS: MY9_0755
Reference
1  [PMID:30181282]
  Authors
Terekhov SS, Smirnov IV, Malakhova MV, Samoilov AE, Manolov AI, Nazarov AS, Danilov DV, Dubiley SA, Osterman IA, Rubtsova MP, Kostryukova ES, Ziganshin RH, Kornienko MA, Vanyushkina AA, Bukato ON, Ilina EN, Vlasov VV, Severinov KV, Gabibov AG, Altman S
  Title
Ultrahigh-throughput functional profiling of microbiota communities.
  Journal
Proc Natl Acad Sci U S A 115:9551-9556 (2018)
DOI:10.1073/pnas.1811250115
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.107
IUBMB Enzyme Nomenclature: 3.1.3.107
ExPASy - ENZYME nomenclature database: 3.1.3.107
BRENDA, the Enzyme Database: 3.1.3.107
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