KEGG ENZYME: 3.1.3.49

ENZYME: 3.1.3.49

Entry

EC 3.1.3.49                 Enzyme

Name

[pyruvate kinase]-phosphatase;
pyruvate kinase phosphatase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases

Sysname

[ATP:pyruvate 2-O-phosphotransferase]-phosphate phosphohydrolase

Reaction(IUBMB)

[pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate [RN:R03993]

Reaction(KEGG)

Substrate

[pyruvate kinase] phosphate [CPD:C03808];
H2O [CPD:C00001]

Product

[pyruvate kinase] [CPD:C02601];
phosphate [CPD:C00009]

Comment

Simultaneously dephosphorylates and activates EC 2.7.1.40 pyruvate kinase, that has been inactivated by protein kinase.

History

EC 3.1.3.49 created 1984

Reference

1 [PMID:6271587]

Authors

Jett MF, Hue L, Hers HG.

Title

Pyruvate kinase phosphatase.

Journal

FEBS Lett 132:183-6 (1981)
DOI:10.1016/0014-5793(81)81156-8

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:	79986-25-7

LinkDB

DBGET integrated database retrieval system