Entry
Name
IMP-specific 5'-nucleotidase;
ISN1 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
inosine 5'-phosphate phosphohydrolase
Reaction(IUBMB)
IMP + H2O = inosine + phosphate [RN:
R01126 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+.
History
EC 3.1.3.99 created 2016
Pathway
Orthology
K18550 IMP and pyridine-specific 5'-nucleotidase
Genes
SMO : SELMODRAFT_103387 SELMODRAFT_413967 SELMODRAFT_415743 SELMODRAFT_99737
PPP : 112282666 112283810 112286598 112287728 112291556 112292774
MPP : MICPUCDRAFT_27168(JGI:MicpuC2_27168)
NCS : NCAS_0H02430(NCAS0H02430)
NDI : NDAI_0C01230(NDAI0C01230)
TPF : TPHA_0J02930(TPHA0J02930)
TBL : TBLA_0D01760(TBLA0D01760)
TDL : TDEL_0A03650(TDEL0A03650)
KAF : KAFR_0C05230(KAFR0C05230)
KNG : KNAG_0B03860(KNAG0B03860)
CAL : CAALFM_C101650WA(ISN1)
NTE : NEUTE1DRAFT55104(NEUTE1DRAFT_55104)
FPOA : FPOAC1_005064(ISN1)
BFU : BCIN_08g04420(Bcisn1)
PBL : PAAG_11311(PAAG_01584)
SPAR : SPRG_11168 SPRG_14401
EHX : EMIHUDRAFT_231552 EMIHUDRAFT_455795
GTT : GUITHDRAFT_163029 GUITHDRAFT_89259
» show all
Taxonomy
Reference
Authors
Itoh R
Title
Purification and some properties of an IMP-specific 5'-nucleotidase from yeast.
Journal
Reference
Authors
Itoh R, Saint-Marc C, Chaignepain S, Katahira R, Schmitter JM, Daignan-Fornier B
Title
The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.99
ExPASy - ENZYME nomenclature database: 3.1.3.99
LinkDB
All DBs