Entry
Name
arginine dihydrolase;
argZ (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
BRITE hierarchy
Sysname
L-arginine aminodihydrolase (L-ornithine-forming)
Reaction(IUBMB)
L-arginine + 2 H2O = L-ornithine + CO2 + 2 ammonia [RN:
R13308 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from different cyanobacterial species, is highly specific to arginine and does not require a metal cofactor. The enzyme from Nostoc is bifunctional, and also catalyses the activity of EC
4.3.1.12 , ornithine cyclodeaminase.
History
EC 3.5.3.27 created 2024
Reference
Authors
Zhang H, Liu Y, Nie X, Liu L, Hua Q, Zhao GP, Yang C.
Title
The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase.
Journal
Sequence
Reference
Authors
Burnat M, Picossi S, Valladares A, Herrero A, Flores E.
Title
Catabolic pathway of arginine in Anabaena involves a novel bifunctional enzyme that produces proline from arginine.
Journal
Sequence
Reference
Authors
Zhuang N, Zhang H, Li L, Wu X, Yang C, Zhang Y.
Title
Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.27
ExPASy - ENZYME nomenclature database: 3.5.3.27
LinkDB
All DBs