Entry Name salsolinol synthase;
Class Hydrolases;BRITE hierarchy
Sysname (R)-salsolinol dopamine-hydrolase (acetaldehyde-forming)
Reaction(IUBMB) (R)-salsolinol + H2O = dopamine + acetaldehyde [RN:
R13309 ]
Reaction(KEGG) Substrate Product Comment The enzyme, present in mammalian brains, forms the catechol isoquinoline (R)-salsolinol. This compound can be metabolized to (R)-N-methylsalsolinol, a 1-methyl-4-phenylpyridinium-like neurotoxin that impairs the function of dopaminergic neurons, causing the clinical symptoms of Parkinson's disease.
History EC 3.5.99.12 created 2024
Reference Authors Naoi M, Maruyama W, Dostert P, Kohda K, Kaiya T.
Title A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol.
Journal Reference Authors Naoi M, Maruyama W, Takahashi T, Akao Y, Nakagawa Y.
Title Involvement of endogenous N-methyl(R)salsolinol in Parkinson's disease: induction of apoptosis and protection by (-)deprenyl.
Journal Reference Authors Chen X, Zheng X, Ali S, Guo M, Zhong R, Chen Z, Zhang Y, Qing H, Deng Y.
Title Isolation and Sequencing of Salsolinol Synthase, an Enzyme Catalyzing Salsolinol Biosynthesis.
Journal Sequence Reference Authors Xiong Q, Zheng X, Wang J, Chen Z, Deng Y, Zhong R, Wang J, Chen X.
Title Sal synthase induced cytotoxicity of PC12 cells through production of the dopamine metabolites salsolinol and N-methyl-salsolinol.
Journal Other DBs ExPASy - ENZYME nomenclature database: 3.5.99.12
LinkDB All DBs
