Entry
Name
4-chlorobenzoyl-CoA dehalogenase
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
4-chlorobenzoyl CoA chlorohydrolase
Reaction(IUBMB)
4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride [RN:
R04101 ]
Reaction(KEGG)
Substrate
Product
4-hydroxybenzoyl CoA;
chloride [CPD:
C00698 ]
Comment
Specific for dehalogenation at the 4-position. Can dehalogenate substrates bearing fluorine, chlorine, bromine and iodine in the 4-position. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.
History
EC 3.8.1.7 created 1999
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K14418 4-chlorobenzoyl-CoA dehalogenase
Reference
Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D
Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
Journal
Sequence
Reference
Authors
Crooks GP, Copley SD
Title
Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.7
ExPASy - ENZYME nomenclature database: 3.8.1.7
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.7
BRENDA, the Enzyme Database: 3.8.1.7
LinkDB
All DBs