ENZYME: 4.1.1.115
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Entry
EC 4.1.1.115 Enzyme
Name
indoleacetate decarboxylase;
IAD
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(1H-indol-3-yl)acetate carboxy-lyase (skatole-forming)
Reaction(IUBMB)
(1H-indol-3-yl)acetate = skatole + CO2 [RN:
R12303
]
Reaction(KEGG)
R12303
Reaction
Substrate
(1H-indol-3-yl)acetate [CPD:
C00954
]
Product
skatole [CPD:
C08313
];
CO2 [CPD:
C00011
]
Comment
This glycyl radical enzyme has been isolate from a number of bacterial species. Skatole contributes to the characteristic smell of animal faeces.
History
EC 4.1.1.115 created 2019
Pathway
ec00380
Tryptophan metabolism
Orthology
K23384
indoleacetate decarboxylase
Genes
CBN
:
CbC4_1610
CSQ
:
CSCA_1772
CDRK
:
B9W14_10435
AFT
:
BBF96_06495
OLS
:
Olsu_0124
Taxonomy
Reference
1 [PMID:
30310076
]
Authors
Liu D, Wei Y, Liu X, Zhou Y, Jiang L, Yin J, Wang F, Hu Y, Nanjaraj Urs AN, Liu Y, Ang EL, Zhao S, Zhao H, Zhang Y
Title
Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole.
Journal
Nat Commun 9:4224 (2018)
DOI:
10.1038/s41467-018-06627-x
Sequence
[csq:
CSCA_1772
]
Other DBs
ExplorEnz - The Enzyme Database:
4.1.1.115
IUBMB Enzyme Nomenclature:
4.1.1.115
ExPASy - ENZYME nomenclature database:
4.1.1.115
BRENDA, the Enzyme Database:
4.1.1.115
LinkDB
All DBs
DBGET
integrated database retrieval system