ENZYME: 4.1.1.118
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Entry
EC 4.1.1.118 Enzyme
Name
isophthalyl-CoA decarboxylase;
IPCD
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
isophthalyl-CoA carboxy-lyase
Reaction(IUBMB)
isophthalyl-CoA = benzoyl-CoA + CO2 [RN:
R12486
]
Reaction(KEGG)
R12486
Reaction
Substrate
isophthalyl-CoA [CPD:
C22204
]
Product
benzoyl-CoA [CPD:
C00512
];
CO2 [CPD:
C00011
]
Comment
The enzyme, characterized from the bacterium Syntrophorhabdus aromaticivorans, participates in an anaerobic isophthalate degradation pathway. The enzyme requires a prenylated flavin mononucleotide cofactor.
History
EC 4.1.1.118 created 2019
Reference
1 [PMID:
30647456
]
Authors
Junghare M, Spiteller D, Schink B
Title
Anaerobic degradation of xenobiotic isophthalate by the fermenting bacterium Syntrophorhabdus aromaticivorans.
Journal
ISME J 13:1252-1268 (2019)
DOI:
10.1038/s41396-019-0348-5
Other DBs
ExplorEnz - The Enzyme Database:
4.1.1.118
IUBMB Enzyme Nomenclature:
4.1.1.118
ExPASy - ENZYME nomenclature database:
4.1.1.118
BRENDA, the Enzyme Database:
4.1.1.118
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DBGET
integrated database retrieval system