Entry
Name
pyrrole-2-carboxylate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
pyrrole-2-carboxylate carboxy-lyase
Reaction(IUBMB)
(1) pyrrole-2-carboxylate = pyrrole + CO2 [RN:
R09794 ];
(2) pyrrole-2-carboxylate + H2O = pyrrole + HCO3- [RN:
R09795 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme catalyses both the carboxylation and decarboxylation reactions. However, while bicarbonate is the preferred substrate for the carboxylation reaction, decarboxylation produces carbon dioxide. The enzyme is activated by carboxylic acids.
History
EC 4.1.1.93 created 2011
Reference
Authors
Wieser M, Fujii N, Yoshida T, Nagasawa T
Title
Carbon dioxide fixation by reversible pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910.
Journal
Reference
Authors
Omura H, Wieser M, Nagasawa T
Title
Pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910, an organic-acid-requiring enzyme.
Journal
Reference
3
Authors
Wieser, M., Yoshida, T. and Nagasawa, T.
Title
Microbial synthesis of pyrrole-2-carboxylate by Bacillus megaterium PYR2910.
Journal
Tetrahedron Lett 39:4309-4310 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.93
ExPASy - ENZYME nomenclature database: 4.1.1.93
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.93
LinkDB
All DBs