KEGG ENZYME: 4.1.2.32

ENZYME: 4.1.2.32

Entry

EC 4.1.2.32                 Enzyme

Name

trimethylamine-oxide aldolase;
trimethylamine N-oxide formaldehyde-lyase;
trimethylamine N-oxide aldolase;
trimethylamine N-oxide demethylase;
trimethylamine-N-oxide formaldehyde-lyase

Class

Lyases;
Carbon-carbon lyases;
Aldehyde-lyases

Sysname

trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)

Reaction(IUBMB)

trimethylamine N-oxide = dimethylamine + formaldehyde [RN:R02512]

Reaction(KEGG)

R02512

Substrate

trimethylamine N-oxide [CPD:C01104]

Product

dimethylamine [CPD:C00543];
formaldehyde [CPD:C00067]

History

EC 4.1.2.32 created 1978

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K28979

trimethylamine-oxide aldolase

Genes

VIH:	AB0763_13415

PRE:	PCA10_14380(gcvT)

PFUW:

KF707C_42100

PCQ:	PcP3B5_34350(gcvT_4)

PFE:	PSF113_3539

PZA:	HU749_012825

PFS:

PFLU_2330

PVR:	PverR02_12510

PMAB:

U0037_11695

PBA:	PSEBR_a2219

PSV:	PVLB_12375

PSK:	U771_12120

PSET:

THL1_1500

PSIL:

PMA3_11120

PVK:	EPZ47_12025

PBZ:	GN234_06145

PMAO:

PMYSY11_0161

PTRT:

HU722_0011555

PPAO:

K3169_15325

PHEF:

PSH57_17130

PSLP:

BHQ29_05660

PDEU:

QEP73_15050

PSIV:

LZ023_17260

PTHV:

CE140_08330

PSNY:

ACPFMA_16190

PSYQ:

HXW90_12310

PSAO:

SK095_20460

PMY:

Pmen_3460

PKH:	JLK41_14795

ECOP:

L0Y47_18040

NJO:	ABXT42_10895

ACIU:

A3K93_14295

ACIG:

BS636_16045

ATV:	ABEF79_16600

ACAZ:

ABJ384_15440

HTR:	EPV75_09235

MPIN:

LGT42_007860

MTHA:

VSX76_01825

HAF:	C8233_03980

CMAI:

BFX80_07320

CAMH:

LCW13_07430

COBE:

CLAM6_13830

COBB:

H2O77_07425

COBC:

F8A90_07230

COBU:

HA399_06915

MSEC:

LN244_01230

NIK:	F5I99_18955

TSN:	W908_05660

THIN:

CRN91_04740

BUZ:	AYM40_12370

PHUN:

U0042_09325

LCH:

Lcho_0155

AON:	DEH84_17430

METR:

BSY238_2317

MEU:	ACJ67_08490

MEDZ:

MTDW_12420

ACOM:

CEW83_16715

MLN:	A9174_29140

MCI:	Mesci_5161

MCIC:

A4R28_01295

MOP:	Mesop_5745

MAM:	Mesau_05240

MAMO:

A6B35_11050

MESW:

A9K65_028290

MESM:

EJ066_15650

MESP:

C1M53_18780

MHUA:

MCHK_0821

MJR:	EB229_29720

MERD:

EB233_25765

MOH:	IHQ72_30500

MMEI:

LRP31_29860

MESJ:

MJ8_18030

MESI:

LGH82_11755

MESU:

LHFGNBLO_005556

MEOR:

ACIU1A_05385

MEIR:

GA829_28850

MESX:

MesoLj131a_52390

AAK:	AA2016_5253

AMIH:

CO731_04987(gcvT_15)

AMIS:

Amn_09790

ANJ:	AMD1_4798(gcvT)

AMIO:

N7E70_026010

AMIW:

H5P29_09985

PHT:	BLM14_24630

SME:

SMc04148

SMK:	Sinme_3435

SMQ:	SinmeB_3210

SMX:	SM11_chr3575

SMI:	BN406_03238

SMEG:

C770_GR4Chr0111

SMEL:

SM2011_c04148

SMER:

DU99_00560

SMD:

Smed_3316

SIX:	BSY16_5786

EAK:	EKH55_4284

SKM:	PZL22_003719

RET:	RHE_PE00406

REL:	REMIM1_PD00428

RLE:

pRL110541

RLT:	Rleg2_5656

RLG:

Rleg_6592

RLB:	RLEG3_05325

RLU:	RLEG12_02035

RHL:	LPU83_pLPU83c0703

RHR:	CKA34_31885

RAD:	CO657_29000

RII:	FFM53_030535

RHID:

FFM81_029880

RLN:	J0663_26930

RBAN:

J2J98_25820

RRG:	J3P73_30850

RAW:	NE851_05330

RLW:	RlegWSM1455_31215

RBW:	RLCC275e_30155

RIF:	U5G49_004832

RHIB:

I8E17_30585

RHIW:

KQ933_29485

RHIP:

NE852_25255

RHIS:

N2A41_31240

RHIO:

P6U16_19040

RRHO:

PR018_16840

RTU:	PR017_16730

RTR:	RTCIAT899_PC09240

RJG:	CCGE525_22890

RLS:	HB780_09365

ARA:	Arad_8379(gcvT)

XAU:

Xaut_3184

AZC:

AZC_1375

LNE:	FZC33_26180

AQI:	J5J86_09155

MOG:	MMB17_17385

MSL:

Msil_3603

MTUN:

MTUNDRAET4_3217

BBAR:

RHAL1_03795

HMC:	HYPMC_2736

METG:

HT051_12805

CMET:

K6K41_17920

AUZ:	Sa4125_10160

JIE:	OH818_23800

NOH:	G5V57_22960

RPOP:

K1718_10525

LIZ:	LGH83_08185

SIL:

SPO1562

RCON:

K3740_20170

RDE:

RD1_3858

RLI:	RLO149_c005760

RFU:	ROLI_041800(gcvT_3)

RALG:

AB4K19_014210

OAR:	OA238_c26870

LMD:	METH_18405

LEJ:	ETW24_17925(tdm)

LAQU:

R2C4_19775(tdm)

LEV:	ETW23_00235(tdm)

LCAE:

K3721_16200(tdm)

CID:

P73_0140

CEH:	CEW89_17230

MALG:

MALG_04228

TPRO:

Ga0080559_TMP4887

PABY:

Ga0080574_TMP1124

SULZ:

C1J03_14670

TOM:	BWR18_13275

TATE:

ACMHLQ_19330

TATY:

ACERHN_00265

RMM:	ROSMUCSMR3_00028(gcvT)

ROK:	RAK1035_2878

RID:	RIdsm_00110(gcvT_1)

ROM:	EI983_02195

ROH:	FIU89_18655(gcvT5)

RPHC:

RZ517_17340

RRL:	RZS32_009365

THAA:

CFI11_06690

MALU:

KU6B_40090

PALX:

GQA70_23210(tdm)

ASCA:

QEZ52_19050(tdm)

ACLD:

ACIRQ6_09915

MATG:

ACMVPR_17815

TSPO:

UM181_13090

FYT:	QF092_01100

PAMI:

JCM7686_pAMI6p069

PYE:	A6J80_01580

PZH:	CX676_01775

PAMN:

pAMV1p0113(tmd)

PSAP:

JHX88_20400

PALP:

JHW40_18580

PHOI:

ACLISE_00345

DAA:	AKL17_0241

TLB:	RPE78_15055

YPHY:

AABB29_04810

GEH:	HYN69_06805

GFU:	KM031_03360

TAW:	EI545_08455

HDH:	G5B40_19255

FAP:	GR316_12230

AMYL:

QBD29_01370

RBG:	BG454_03395

BOSG:

GKR98_01450

MANH:

LA6_001842(gcvT_5)

MASX:

ACK3BB_16305

RHP:	LPB142_05615

SSAN:

NX02_15605

GBE:	GbCGDNIH1_1824

GBH:	GbCGDNIH2_1824

GBC:	GbCGDNIH3_1824

GBS:	GbCGDNIH4_1824

GXL:

H845_66

KEU:	S101446_00772(gcvT)

AACE:

A0U92_02460

ACEK:

FLP30_07300

NGU:	QN315_14160

HTQ:	FRZ44_22590

HADH:

FRZ61_24600

TII:	DY252_08085

THAI:

IT893_13175

TTB:	MACH01_26140

THGO:

M9H61_20580

PUB:	SAR11_1303

PEG:	E5R92_06735

PELA:

B5L73_02295

APC:	HIMB59_00013390

APM:	HIMB5_00009420

SAQI:

AXG55_13515

MADI:

A7U43_20120

MYW:	BVC93_02810

MYJ:	BCA37_09025

MVA:

Mvan_1202

MAUS:

JN090_04735

MGI:

Mflv_5134

MSP:	Mspyr1_45540

MPHL:

MPHLCCUG_02554(gcvT_2)

MVQ:

MYVA_1578

MHAS:

MHAS_01948(gcvT_2)

MAUU:

NCTC10437_00994(gcvT_1)

MMOR:

MMOR_34880

MTY:	MTOK_34470

MPOF:

MPOR_14900

MDF:	K0O62_10915

MFRE:

EXE63_03860

MPAT:

MPNTM1_00298

CIG:	E7744_01475

PBAJ:

LRS13_14120

LET:	O77CONTIG1_04437(gcvT_3)

LEPI:

EDM05_038140

THEU:

HPC62_19235

TOG:	HNI00_15935

» show all

Reference

1 [PMID:11946146]

Authors

Large PJ.

Title

Non-oxidative demethylation of trimethylamine N-oxide by Pseudomonas aminovorans.

Journal

FEBS Lett 18:297-300 (1971)
DOI:10.1016/0014-5793(71)80470-2

Reference

2 [PMID:5116524]

Authors

Myers PA, Zatman LJ.

Title

The metabolism of trimethylamine N-oxide by Bacillus PM6.

Journal

Biochem J 121:10P (1971)
DOI:10.1042/bj1210010pa

Other DBs

ExplorEnz - The Enzyme Database:

4.1.2.32

IUBMB Enzyme Nomenclature:

4.1.2.32

ExPASy - ENZYME nomenclature database:

4.1.2.32

UM-BBD (Biocatalysis/Biodegradation Database):

4.1.2.32

BRENDA, the Enzyme Database:

4.1.2.32

CAS:	72561-08-1

LinkDB

DBGET integrated database retrieval system