KEGG ENZYME: 4.1.2.59

ENZYME: 4.1.2.59

Entry

EC 4.1.2.59                 Enzyme

Name

dihydroneopterin phosphate aldolase;
H2NMP aldolase

Class

Lyases;
Carbon-carbon lyases;
Aldehyde-lyases

Sysname

7,8-dihydroneopterin 3'-phosphate glycolaldehyde phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]

Reaction(IUBMB)

7,8-dihydroneopterin 3'-phosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde phosphate [RN:R11718]

Reaction(KEGG)

R11718

Substrate

7,8-dihydroneopterin 3'-phosphate [CPD:C05925]

Product

6-(hydroxymethyl)-7,8-dihydropterin [CPD:C01300];
glycolaldehyde phosphate [CPD:C21614]

Comment

The enzyme participates in methanopterin biosynthesis the archaeon Pyrococcus furiosus. The enzyme is specific for 7,8-dihydroneopterin 3'-phosphate. cf. EC 4.1.2.25, dihydroneopterin aldolase and EC 4.1.2.60, dihydroneopterin triphosphate aldolase.

History

EC 4.1.2.59 created 2017

Pathway

ec00790

Folate biosynthesis

ec01100

Metabolic pathways

Orthology

K22102

dihydroneopterin phosphate aldolase

Genes

PGF:	J0G10_28675

PFU:

PF1278

PFI:

PFC_05605

PHO:	PH0634(PH0634)

PAB:

PAB1445

PYN:

PNA2_1253

PYA:	PYCH_10490

PYS:

Py04_1120

PYC:	TQ32_04640

TKO:

TK1119

TON:

TON_0580

TGA:	TGAM_1368(ptpS-1)

TSI:

TSIB_0131

TBA:	TERMP_00739

THE:

GQS_02170

THA:

TAM4_2194

THM:

CL1_0002

TLT:

OCC_07001

THS:

TES1_0816

TNU:

BD01_0806

TEU:

TEU_08715

TGY:	X802_10605

THV:	ADU37_CDS00510

TCH:	CHITON_0626

TPEP:

A0127_09300

TPIE:

A7C91_08915

TGG:	A3K92_03845

TCE:	A3L02_02165

TBS:	A3L01_03615

THH:	CDI07_03555

TSL:	A3L11_07605

TTD:	A3L14_05300

TPRF:

A3L09_06605

TRL:	A3L10_02950

TPAF:

A3L08_06745

THY:	A3L12_05350

TIC:	FH039_06250

TCQ:	TIRI35C_0957

THEM:

FPV09_03090

THEI:

K1720_03735

PPAC:

PAP_06685

» show all

Reference

1 [PMID:22931285]

Authors

de Crecy-Lagard V, Phillips G, Grochowski LL, El Yacoubi B, Jenney F, Adams MW, Murzin AG, White RH

Title

Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of tetrahydromethanopterin and tetrahydrofolate.

Journal

ACS Chem Biol 7:1807-16 (2012)
DOI:10.1021/cb300342u

Sequence

[pfu:PF1278]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.2.59

IUBMB Enzyme Nomenclature:

4.1.2.59

ExPASy - ENZYME nomenclature database:

4.1.2.59

BRENDA, the Enzyme Database:

4.1.2.59

LinkDB

DBGET integrated database retrieval system