Entry
Name
2-dehydro-3-deoxy-D-arabinonate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-D-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-D-arabinonate = 2,5-dioxopentanoate + H2O [RN:
R09186 ]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-D-arabinonate [CPD:
C03826 ]
Product
Comment
The enzyme participates in pentose oxidation pathways that convert pentose sugars to the tricarboxylic acid cycle intermediate 2-oxoglutarate.
History
EC 4.2.1.141 created 2013
Pathway
ec00040 Pentose and glucuronate interconversions
ec00053 Ascorbate and aldarate metabolism
Orthology
K14259 2-dehydro-3-deoxy-D-arabinonate dehydratase
Genes
GJF : M493_09690 M493_10125
FEC : QNH15_22290 QNH15_23735
MEKU : HUW50_20550 HUW50_22775
ERZ : ER308_02575 ER308_18835
LEIF : HF024_03020 HF024_15480
MRG : SM116_15335 SM116_16455
GRY : D7I44_08845 D7I44_11540
NAK : EH165_00860 EH165_12535
ARHD : VSH64_07530 VSH64_16880
MTAR : DF168_01379(yisK_2)
TPLA : ElP_33080 ElP_41610
MUH : HYN43_007300 HYN43_020440
MGK : FSB76_02295 FSB76_16455
PSEZ : HME7025_01774(kdxD)
EMZ : MB380_02360 MB380_19605
HALR : EFA46_010930 EFA46_011065
HALJ : G9465_01195 G9465_10995
HRR : HZS55_16705 HZS55_21925
HPEL : HZS54_19520 HZS54_25415
HLT : I7X12_14460 I7X12_18970
HGI : ABY42_15580 ABY42_16735
SRUB : C2R22_00805 C2R22_01260
HALU : HUG12_05225 HUG12_08670
HSAL : JMJ58_23245 JMJ58_23350
HXA : Halxa_3765 Halxa_3794
HLR : HALLA_01780 HALLA_04540
» show all
Taxonomy
Reference
Authors
Brouns SJ, Walther J, Snijders AP, van de Werken HJ, Willemen HL, Worm P, de Vos MG, Andersson A, Lundgren M, Mazon HF, van den Heuvel RH, Nilsson P, Salmon L, de Vos WM, Wright PC, Bernander R, van der Oost J
Title
Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment.
Journal
Sequence
Reference
Authors
Brouns SJ, Barends TR, Worm P, Akerboom J, Turnbull AP, Salmon L, van der Oost J
Title
Structural insight into substrate binding and catalysis of a novel 2-keto-3-deoxy-D-arabinonate dehydratase illustrates common mechanistic features of the FAH superfamily.
Journal
Sequence
Reference
Authors
Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schonheit P
Title
D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.141
LinkDB
All DBs