Entry
Name
phosphomevalonate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
R-5-phosphomevalonate hydro-lyase
Reaction(IUBMB)
(R)-5-phosphomevalonate = trans-anhydromevalonate 5-phosphate + H2O [RN:
R12894 ]
Reaction(KEGG)
Substrate
(R)-5-phosphomevalonate [CPD:
C01107 ]
Product
trans-anhydromevalonate 5-phosphate [CPD:
C22453 ];
H2O [CPD:
C00001 ]
Comment
The enzyme catalyses a step in an archaeal prenyl diphosphate biosynthesis pathway. It belongs to the aconitase X family, and contains a [4Fe-4S] cluster.
History
EC 4.2.1.182 created 2023
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K09128 phosphomecalonate degydratase small subunit
K25517 phosphomecalonate degydratase large subunit
Genes
AGAT : RWV98_01370 RWV98_05425 RWV98_05430
CHYL : CE91St63_25950 CE91St63_25960
MFE : Mefer_0080 Mefer_1421
MVU : Metvu_1202 Metvu_1439
MFS : MFS40622_0336 MFS40622_0378
MIF : Metin_0203 Metin_0709
MJH : JH146_0315 JH146_0335
MESG : MLAUSG7_1120 MLAUSG7_1129
MESA : MLASG1_0646 MLASG1_0655
MIG : Metig_1406 Metig_1502
MMQ : MmarC5_0709 MmarC5_1745
MMX : MmarC6_1010 MmarC6_1754
MMZ : MmarC7_0149 MmarC7_0935
MMAK : MMKA1_09990 MMKA1_18950
MMAO : MMOS7_09770 MMOS7_17760
MMAD : MMJJ_00900 MMJJ_11690
MVN : Mevan_0019 Mevan_0963
MOK : Metok_0423 Metok_0993
METF : CFE53_03445 CFE53_03920
MMG : MTBMA_c00090 MTBMA_c01130
MWO : MWSIV6_0069 MWSIV6_1799
MTEE : MTTB_00060 MTTB_15270
METC : MTCT_1292 MTCT_1393
METE : tca_01372 tca_01478
METZ : METMT2_0007 METMT2_0081
METK : FVF72_03975 FVF72_04490
MTHM : FZP57_00285 FZP57_08815
METJ : FZP68_01415 FZP68_01915
METB : AW729_06040 AW729_07300
MEIS : PXD04_03700 PXD04_04930
MEYE : TL18_10020 TL18_10225
MARO : MarbSA_10890 MarbSA_11580
METV : K4897_05435 K4897_05640
MEL : Metbo_0003 Metbo_0105
MEW : MSWAN_0095 MSWAN_2414
METH : MBMB1_0075 MBMB1_2037
MFI : DSM1535_1324 DSM1535_1462
MCUB : MCBB_0100 MCBB_2333
MSUB : BK009_09450 BK009_09950
METN : BK008_05200 BK008_05790
METT : CIT01_05450 CIT01_06045
METO : CIT02_06640 CIT02_07305
MEME : HYG87_06310 HYG87_06935
MFEG : GCM10025860_07210 GCM10025860_08750
AFG : AFULGI_00000480 AFULGI_00026330
APO : Arcpr_0690 Arcpr_1395
AVE : Arcve_0619 Arcve_1712
AST : Asulf_00141 Asulf_00994
PHO : PH0353(PH0353) PH0354(PH0354)
PYA : PYCH_13830 PYCH_13840
PYC : TQ32_03560 TQ32_03565
TGA : TGAM_1119(acnX) TGAM_1120(acnX)
TBA : TERMP_00892 TERMP_00893
TGY : X802_08765 X802_08770
THV : ADU37_CDS20780 ADU37_CDS20790
TCH : CHITON_1180 CHITON_1181
TPEP : A0127_08680 A0127_08685
TPIE : A7C91_08615 A7C91_08620
TGG : A3K92_05205 A3K92_05210
TCE : A3L02_02475 A3L02_02480
TBS : A3L01_03300 A3L01_03305
THH : CDI07_03235 CDI07_03240
TSL : A3L11_07275 A3L11_07280
TTD : A3L14_04985 A3L14_04990
TPRF : A3L09_07630 A3L09_07635
TRL : A3L10_03265 A3L10_03270
TPAF : A3L08_06355 A3L08_06360
THY : A3L12_05565 A3L12_05570
TIC : FH039_05850 FH039_05855
TCQ : TIRI35C_0894 TIRI35C_0895
THEM : FPV09_03495 FPV09_03500
THEI : K1720_02455 K1720_02460
PPAC : PAP_03695 PAP_03700
MBA : Mbar_A0717 Mbar_A0718
MBY : MSBRM_0327 MSBRM_0328
MBW : MSBRW_0283 MSBRW_0284
MBAR : MSBR2_2053 MSBR2_2054
MBAK : MSBR3_2122 MSBR3_2123
MMAZ : MmTuc01_1583 MmTuc01_1584
MMJ : MSMAS_3142 MSMAS_3143
MMAC : MSMAC_3162 MSMAC_3163
MVC : MSVAZ_0316 MSVAZ_0317
MEK : MSKOL_0300 MSKOL_0301
MLS : MSLAZ_0092 MSLAZ_0093
METM : MSMTP_3040 MSMTP_3041
MEF : MSWH1_0171 MSWH1_0172
MEQ : MSWHS_0170 MSWHS_0171
MSJ : MSSAC_0230 MSSAC_0231
MSZ : MSSIH_0199 MSSIH_0200
MSW : MSSIT_0203 MSSIT_0204
MTHR : MSTHT_2040 MSTHT_2041
MTHE : MSTHC_1245 MSTHC_1246
MHOR : MSHOH_3879 MSHOH_3880
MFZ : AOB57_009515 AOB57_009520
MMET : MCMEM_1971 MCMEM_1972
MELO : J7W08_08745 J7W08_08750
MHAZ : BHR79_04820 BHR79_04825
MPOT : BKM01_00945 BKM01_00950
MEV : Metev_2054 Metev_2055
MZH : Mzhil_1539 Mzhil_1540
MZI : HWN40_10875 HWN40_10880
MMAV : RE476_12220 RE476_12225
MSEB : RE474_09110 RE474_09115
MHZ : Metho_2163 Metho_2164
MEHF : MmiHf6_15590 MmiHf6_15600
MEES : MmiEs2_00950 MmiEs2_00960
MRTJ : KHC33_11740 KHC33_16800
MEM : Memar_1309 Memar_2138
MBG : BN140_1346 BN140_2051
MEMA : MMAB1_1715 MMAB1_2659
MCHK : MchiMG62_14940 MchiMG62_24470
MSUM : OH143_00780 OH143_04975
MRC : R6Y96_01585 R6Y96_07365
MEND : L6E24_01025 L6E24_10800
MEFW : F1737_02315 F1737_03010
MAQE : RJ40_06745 RJ40_12530
MFK : E2N92_00350 E2N92_06910
MOU : OU421_09620 OU421_11465
MESB : L1S32_00815 L1S32_03355
MANQ : L1994_03865 L1994_07210
MFO : Metfor_0251 Metfor_1534
HALH : HTSR_1040 HTSR_1041
HHSR : HSR6_1073 HSR6_1074
HSU : HLASF_0830 HLASF_0831
HSF : HLASA_0827 HLASA_0828
HAHS : HSRCO_1216 HSRCO_1217
HALA : Hrd1104_02525 Hrd1104_02530
HASV : SVXHr_1978 SVXHr_1979
HABN : HBNXHr_1965 HBNXHr_1966
HDS : HSR122_0650 HSR122_0651
HARC : HARCEL1_02635 HARCEL1_02640
HDF : AArcSl_1771 AArcSl_1772
HAAA : AArcCO_0145 AArcCO_0146
MEAM : MU439_04160 MU439_04165
MEAE : QEN48_05810 QEN48_05815
TAR : TALC_00511 TALC_00512
MAX : MMALV_04600 MMALV_04610
MER : MMINT_07310 MMINT_07320
MEAR : Mpt1_c03820 Mpt1_c03830(nudI)
MEUZ : KRP56_05840 KRP56_05845
MARC : AR505_0453 AR505_0454
ACF : AciM339_0156 AciM339_0157
SHC : Shell_0172 Shell_0173
DFD : Desfe_0217 Desfe_0218
DMU : Desmu_0693 Desmu_0694
THG : TCELL_0122 TCELL_0123
PFM : Pyrfu_0193 Pyrfu_0194
PDL : Pyrde_0502 Pyrde_0503
PABI : PABY_02540 PABY_02550
PARE : PYJP_14510 PYJP_14520
PYW : PYWP30_01479 PYWP30_01480
THB : N186_05490 N186_05495
TCB : TCARB_0165 TCARB_0166
THF : MA03_05620 MA03_05625
THEL : IG193_03585 IG193_03590
ACIA : SE86_01575 SE86_01580
CLG : Calag_0818 Calag_0819
FFO : FFONT_1070 FFONT_1071
NIR : NSED_09895 NSED_09900
NKR : NKOR_00040 NKOR_00045
NID : NPIRD3C_0317 NPIRD3C_0318
NIN : NADRNF5_0013 NADRNF5_0014
NIW : Nisw_04720 Nisw_04725
NCL : C5F47_00265 C5F47_00270
NOX : C5F49_00260 C5F49_00265
NIP : NsoK4_08930 NsoK4_08935
NZT : NZOSNM25_002057 NZOSNM25_002058
NIC : DSQ20_00305 DSQ20_00310
NGA : Ngar_c08140 Ngar_c08150
NVN : NVIE_012770 NVIE_012780
TAA : NMY3_03541 NMY3_03542
NFN : NFRAN_0895 NFRAN_0896
CSY : CENSYa_1907 CENSYa_1908
TAH : SU86_006495 SU86_006500
NIU : DSQ19_10210 DSQ19_10215
NCK : QVH35_02940 QVH35_02950
CCAI : NAS2_0339 NAS2_1614
BARC : AOA65_2273 AOA65_2274
FLT : Sv326_0059 Sv326_0060
LOKI : Lokiarch_22740 Lokiarch_22750
» show all
Taxonomy
Reference
Authors
Yoshida R, Yoshimura T, Hemmi H.
Title
Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells.
Journal
Sequence
Reference
Authors
Komeyama M, Kanno K, Mino H, Yasuno Y, Shinada T, Ito T, Hemmi H.
Title
A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.182
LinkDB
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