ENZYME: 4.2.3.166 Help
Entry
Name
(+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol + diphosphate [RN:
R11831 ]
Reaction(KEGG)
Substrate
Product
(+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol [CPD:
C21686 ];
diphosphate [CPD:
C00013 ]
Comment
The enzyme has been identified in the bacterium Streptomyces pratensis. It is specific for (2E,6E)-farnesyl diphosphate.
History
EC 4.2.3.166 created 2017
Orthology
K23024 (+)-(1E,4E,6S,7R)-germacra-1(10),4-dien-6-ol synthase
Genes
Taxonomy
Reference
Authors
Rabe P, Barra L, Rinkel J, Riclea R, Citron CA, Klapschinski TA, Janusko A, Dickschat JS
Title
Conformational Analysis, Thermal Rearrangement, and EI-MS Fragmentation Mechanism of (1(10)E,4E,6S,7R)-Germacradien-6-ol by (13)C-Labeling Experiments.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.3.166
LinkDB
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