Entry
Name
(2Z,6E)-hedycaryol synthase;
HcS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (2Z,6E)-hedycaryol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate [RN:
R11852 ]
Reaction(KEGG)
Substrate
Product
Comment
Isolated from the bacterium Kitasatospora setae. The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. See also EC
4.2.3.174 (2E,6E)-hedycaryol synthase.
History
EC 4.2.3.187 created 2017
Orthology
K23046 (2Z,6E)-hedycaryol synthase
Genes
KSK : KSE_00200t KSE_76540t
Taxonomy
Reference
Authors
Baer P, Rabe P, Citron CA, de Oliveira Mann CC, Kaufmann N, Groll M, Dickschat JS
Title
Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.3.187
LinkDB
All DBs