ENZYME: 4.2.3.191
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Entry
EC 4.2.3.191 Enzyme
Name
cycloaraneosene synthase;
SdnA
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cycloaraneosene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = cycloaraneosene + diphosphate [RN:
R11858
]
Reaction(KEGG)
R11858
Reaction
Substrate
geranylgeranyl diphosphate [CPD:
C00353
]
Product
cycloaraneosene [CPD:
C21726
];
diphosphate [CPD:
C00013
]
Comment
Isolated from the fungus Sordaria araneosa. Cycloaraneosene is a precursor of the antibiotic sordarin.
History
EC 4.2.3.191 created 2017
Orthology
K22542
cycloaraneosene synthase
Genes
ELA
:
UCREL1_7390
Taxonomy
Reference
1 [PMID:
27072286
]
Authors
Kudo F, Matsuura Y, Hayashi T, Fukushima M, Eguchi T
Title
Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.
Journal
J Antibiot (Tokyo) 69:541-8 (2016)
DOI:
10.1038/ja.2016.40
Sequence
[ag:
BAV32145
]
Other DBs
ExplorEnz - The Enzyme Database:
4.2.3.191
IUBMB Enzyme Nomenclature:
4.2.3.191
ExPASy - ENZYME nomenclature database:
4.2.3.191
BRENDA, the Enzyme Database:
4.2.3.191
LinkDB
All DBs
DBGET
integrated database retrieval system