| Entry |
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| Name |
trichodiene synthase;
trichodiene synthetase;
sesquiterpene cyclase;
trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase
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| Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
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| Sysname |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)
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| Reaction(IUBMB) |
(2E,6E)-farnesyl diphosphate = trichodiene + diphosphate [RN: R02306]
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| Reaction(KEGG) |
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| Substrate |
(2E,6E)-farnesyl diphosphate [CPD: C00448]
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| Product |
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| History |
EC 4.2.3.6 created 1989 as EC 4.1.99.6, transferred 2000 to EC 4.2.3.6
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| Pathway |
| ec00909 | Sesquiterpenoid and triterpenoid biosynthesis |
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| Orthology |
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| Genes |
| FPOA: | FPOAC1_005923(TRI5) |
| AMUS: | LMH87_000337 LMH87_003972 |
» show all
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| Reference |
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| Authors |
Hohn TM, Vanmiddlesworth F. |
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| Title |
Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides. |
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| Journal |
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| Reference |
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| Authors |
Hohn TM, Beremand PD |
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| Title |
Isolation and nucleotide sequence of a sesquiterpene cyclase gene from the trichothecene-producing fungus Fusarium sporotrichioides. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Rynkiewicz MJ, Cane DE, Christianson DW |
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| Title |
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.3.6 |
| ExPASy - ENZYME nomenclature database: | 4.2.3.6 |
| BRENDA, the Enzyme Database: | 4.2.3.6 |
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| LinkDB |
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