ENZYME: 4.2.3.77
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Entry
EC 4.2.3.77 Enzyme
Name
(+)-germacrene D synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-D-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate [RN:
R09558
]
Reaction(KEGG)
R09558
Reaction
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448
]
Product
(+)-germacrene D [CPD:
C19619
];
diphosphate [CPD:
C00013
]
Comment
Requires Mg2+, Mn2+, Ni2+ or Co2+. The formation of (+)-germacrene D involves a 1,2-hydride shift whereas for (-)-germacrene D there is a 1,3-hydride shift (see EC
4.2.3.75
).
History
EC 4.2.3.77 created 2011
Orthology
K22057
(+)-germacrene D synthase
Reference
1 [PMID:
16839518
]
Authors
Picaud S, Olsson ME, Brodelius M, Brodelius PE
Title
Cloning, expression, purification and characterization of recombinant (+)-germacrene D synthase from Zingiber officinale.
Journal
Arch Biochem Biophys 452:17-28 (2006)
DOI:
10.1016/j.abb.2006.06.007
Sequence
[ag:
AAX40665
]
Other DBs
ExplorEnz - The Enzyme Database:
4.2.3.77
IUBMB Enzyme Nomenclature:
4.2.3.77
ExPASy - ENZYME nomenclature database:
4.2.3.77
BRENDA, the Enzyme Database:
4.2.3.77
LinkDB
All DBs
DBGET
integrated database retrieval system