KEGG ENZYME: 4.3.2.8

ENZYME: 4.3.2.8

Entry

EC 4.3.2.8                  Enzyme

Name

gamma-glutamylamine cyclotransferase;
GGACT

Class

Lyases;
Carbon-nitrogen lyases;
Amidine-lyases

Sysname

epsilon-(gamma-L-glutamyl)-L-lysine gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)

Reaction(IUBMB)

epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline [RN:R11862]

Reaction(KEGG)

R11862

Substrate

epsilon-(gamma-L-glutamyl)-L-lysine [CPD:C21730]

Product

L-lysine [CPD:C00047];
5-oxo-L-proline [CPD:C01879]

Comment

The enzyme, found in vertebrates, has no activity toward alpha-(gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.

History

EC 4.3.2.8 created 2017

Orthology

K19761

gamma-glutamylamine cyclotransferase

Genes

HSA:	87769(GGACT)

PTR:	467312(GGACT)

PPS:	100990143(GGACT)

GGO:	101126135(GGACT)

PON:	100457387(GGACT)

PPYG:

129011168(GGACT)

NLE:	100591216(GGACT)

HMH:	116467466(GGACT)

SSYN:

129463558(GGACT)

MCC:	706006(GGACT)

MCF:	102129401(GGACT)

MTHB:

126940223

MNI:	105477942(GGACT)

CSAB:

103214721(GGACT)

CATY:

105574442(GGACT)

PANU:

101025128(GGACT)

TGE:	112610666(GGACT)

MLEU:

105549314 105549315(GGACT)

RRO:	104666433(GGACT)

RBB:	108521787(GGACT)

TFN:	117063551(GGACT)

PTEH:

111546556(GGACT)

CANG:

105505867(GGACT)

CJC:	100414329(GGACT)

SBQ:	101032623(GGACT)

CIMI:

108286007(GGACT)

ANAN:

105709124(GGACT) 105710322

MMUR:

105864189(GGACT)

LCAT:

123649322(GGACT)

ERUF:

138382956(GGACT)

PCOQ:

105810429(GGACT)

OGA:	100963300(GGACT)

MMU:	223267(Ggact)

MCAL:

110309872(Ggact)

MPAH:

110325995(Ggact)

RNO:	290500(Ggact)

MCOC:

116084664(Ggact)

ANU:	117705505(Ggact)

ASYL:

127691010(Ggact)

MUN:	110552856(Ggact)

CGE:	100765817(Ggact)

MAUA:

101841111(Ggact)

PROB:

127230087(Ggact)

PLEU:

114692497(Ggact)

PMAV:

102907329(Ggact)

MORG:

121455681(Ggact)

MFOT:

126506645

AAMP:

119800228(Ggact)

CNL:	130884763(Ggact)

NGI:	103733830(Ggact)

HGL:	101706691(Ggact)

CPOC:

100722666(Ggact)

CCAN:

109684492(Ggact)

DORD:

105990566(Ggact)

DSP:	122122764(Ggact)

DMER:

138813997(Ggact)

PLOP:

125348136(Ggact)

NCAR:

124985474

SVUL:

306660425(GGACT)

MMMA:

107140927(Ggact)

ITI:	101972424(Ggact)

OCU:

100355696

OPI:	101532906(GGACT)

OCZ:	121163476(GGACT)

TUP:	102496174(GGACT)

GVR:	103590215(GGACT)

CFA:	485534(GGACT)

CLUD:

112655765(GGACT)

VVP:	112923809(GGACT)

VLG:	121476985(GGACT)

NPO:	129516538(GGACT)

AML:	100472909(GGACT)

UMR:	103657637(GGACT)

UAH:	113251507(GGACT)

UAR:	123801141(GGACT)

ELK:

111147042

LLV:

125094792

MPUF:

101691002(GGACT)

MNP:	132002879(GGACT)

MLK:	131813456(GGACT)

NVS:	122907220(GGACT)

ORO:	101374021(GGACT)

EJU:	114215888(GGACT)

ZCA:	113919303(GGACT)

MLX:	118009263(GGACT)

MANO:

123839867(GGACT)

NSU:	110585903(GGACT)

LWW:	102741654(GGACT)

FCA:	101084676(GGACT)

PYU:	121037756(GGACT)

PCOO:

112861521(GGACT)

PBG:	122484445(GGACT)

PVIV:

125168219(GGACT)

LRUF:

124513494

LGF:	123599449(GGACT)

AJU:

106978323

PTG:	102961348(GGACT)

PPAD:

109264107(GGACT)

PUC:

125933925

PLEZ:

122214521(GGACT)

HHV:	120246660(GGACT)

CCRU:

144223199(GGACT)

BTA:	512596(GGACT)

BOM:	102274301(GGACT)

BJV:	133258571(GGACT)

BBUB:

102404026(GGACT)

BKE:	129624718(GGACT)

BBIS:

104982166(GGACT)

CHX:	102168275(GGACT)

OAS:	114116642(GGACT)

OCAN:

138446696(GGACT)

BTAX:

128057805(GGACT)

CSUM:

138089258(GGACT)

ODA:	120883346(GGACT)

CCAD:

122447658(GGACT)

MREE:

136144306(GGACT)

OVR:	110140255(GGACT)

MBEZ:

129556478(GGACT)

SSC:	100524456(GGACT)

CFR:	102509572(GGACT)

CBAI:

105072656(GGACT)

CDK:	105094104(GGACT)

VPC:	102537651(GGACT)

BACU:

102997400(GGACT)

BMUS:

118883971(GGACT)

LVE:	103079420(GGACT)

OOR:	101286126(GGACT)

LALB:

132508531(GGACT)

GMF:	115853399(GGACT)

DDP:	132413671(GGACT)

SCOO:

307176932(GGACT)

DLE:	111176421(GGACT)

PCAD:

102983704(GGACT)

PSIU:

116743035(GGACT)

PPHC:

136137840(GGACT)

NASI:

112396359(GGACT)

ECB:	100062328(GGACT)

EPZ:	103559473(GGACT)

EAI:	106829939(GGACT)

MYB:	102243964(GGACT) 102261496

MMYO:

118649786(GGACT) 118674871

MLF:	102424053 102435680(GGACT)

MDT:	132217524 132228515(GGACT)

MYUM:

138997181 139004943(GGACT)

PKL:	118728279(GGACT)

EFUS:

103288253(GGACT)

MNA:	107530179(GGACT)

DRO:	112321427(GGACT)

SHON:

119000697(GGACT)

AJM:	119047876(GGACT)

PDIC:

114508361(GGACT)

PHAS:

123807705(GGACT)

MMF:	118623050(GGACT)

PPAM:

129071191(GGACT)

HAI:	109393926(GGACT)

RFQ:	117021259(GGACT)

PALE:

102892246(GGACT)

PGIG:

120591648(GGACT)

PVP:	105294141(GGACT)

RAY:	107499198(GGACT)

MJV:	108400792(GGACT)

TOD:	119259761(GGACT)

SARA:

101542334(GGACT)

SFUM:

130019191(GGACT)

SETR:

126016103(GGACT)

LAV:	100674734(GGACT)

TMU:

101358174

ETF:	101660146(GGACT)

DNM:	101428583(GGACT)

MDO:	100025919(GGACT)

GAS:	123242639(GGACT)

SHR:	100933308(GGACT)

AFZ:

127553413

PCW:	110192688(GGACT)

TVP:	118845446(GGACT)

PBRV:

138143026(GGACT)

MLAO:

141491241(GGACT)

OAA:	100083163(GGACT)

TACU:

119939408(GGACT)

GGA:	418773(GGACT)

PCOC:

116242745(GGACT)

MGP:	100539854(GGACT)

CJO:	107307978(GGACT)

TPAI:

128071598(GGACT)

LMUT:

125687901(GGACT)

NMEL:

110407858(GGACT)

APLA:

101797829(GGACT)

AACU:

137854402(GGACT)

OJA:	118162499(GGACT)

ACYG:

106031813(GGACT)

CATA:

118253062(GGACT)

AFUL:

116489435(GGACT)

TGU:	100230411(GGACT)

LSR:	110470541(GGACT)

VMC:	128822791(GGACT)

VCHA:

128783039(GGACT)

AIB:	137469614(GGACT)

SCAN:

103812293(GGACT)

PMOA:

120512288(GGACT)

OTC:	121345974(GGACT)

PRUF:

121359363(GGACT)

ATRC:

139591807(GGACT)

MATE:

118692878(GGACT)

MAEN:

136553535(GGACT)

GFR:	102033786(GGACT)

FAB:	101806780(GGACT)

OMA:	130256445(GGACT)

PHI:	102107464(GGACT)

PMAJ:

107205969(GGACT)

CCAE:

111945272(GGACT)

CCW:	104685982(GGACT)

CBRC:

103615689(GGACT)

ACOE:

138106732(GGACT)

ETL:	114065866(GGACT)

ZAB:	102072775(GGACT)

ZLE:	135447264(GGACT)

ACHL:

103808721(GGACT)

SVG:	106851430(GGACT)

MMEA:

130573628(GGACT)

HRT:	120748423(GGACT)

SATI:

136357866(GGACT)

CFAI:

136285346(GGACT)

CCIC:

134057852(GGACT)

NNT:	104402753(GGACT)

SHAB:

115603929(GGACT)

POCC:

134166734(GGACT)

FPG:	101913916(GGACT)

FCH:	102047914(GGACT)

FRS:	119143646(GGACT)

CCRI:

104168630(GGACT)

ACUN:

113477081(GGACT)

ANOC:

141962627(GGACT)

SURA:

141939496(GGACT)

TALA:

104358138(GGACT)

ACHC:

115350776(GGACT)

HALD:

104322361(GGACT)

HLE:	104838525(GGACT)

AGEN:

126045265

HHAR:

128141137(GGACT)

BBUT:

142039458(GGACT)

GCL:

127029622

CSTI:

104562023(GGACT)

LDI:	104348680(GGACT)

MNB:	103774207(GGACT)

DPUB:

104304494(GGACT)

PPUS:

135175546(GGACT)

IIN:	128973600(GGACT)

AVIT:

104279226(GGACT)

BRHI:

104493426(GGACT)

EGZ:	104126250(GGACT)

NNI:	104017193(GGACT)

PCRI:

104029448(GGACT)

PCAO:

104046875(GGACT)

PARX:

142056021(GGACT)

PADL:

103924757(GGACT)

AFOR:

103906399(GGACT)

FGA:	104073429(GGACT)

CBOR:

142075866(GGACT)

GSTE:

104257971(GGACT)

CBOY:

140646278(GGACT)

MAME:

142421592(GGACT)

CLV:	102089959(GGACT)

CNIC:

135990163(GGACT)

MUI:	104547073(GGACT)

PGUU:

104469528(GGACT)

PLET:

104617526(GGACT)

EHS:	104514176(GGACT)

CMAC:

104479147(GGACT)

CUCA:

104060253(GGACT)

PCUR:

138732530(GGACT)

TEO:	104373786(GGACT)

BREG:

104633460(GGACT)

GAME:

129204701(GGACT)

OHA:	104328435(GGACT)

ACAR:

104525299(GGACT)

CPEA:

104388999(GGACT)

CVF:	104292455(GGACT)

RTD:	128904119(GGACT)

CRID:

134516639(GGACT)

LMIC:

141732829(GGACT)

NARQ:

141470711(GGACT)

AAM:	106494035(GGACT)

AROW:

112966438(GGACT)

NPD:	112946506(GGACT)

TGT:	104574058(GGACT)

DNE:	112996221(GGACT)

SCAM:

104147418(GGACT)

ASN:	102369919(GGACT)

AMJ:	102557920(GGACT)

CPOO:

109306364(GGACT)

GGN:	109302717(GGACT)

PSS:	102452312(GGACT)

CIZ:	142010972(GGACT)

CMY:	102931178(GGACT)

CCAY:

125638492(GGACT)

LKP:	140913106(GGACT)

NDS:	141993530(GGACT)

DCC:	119849639(GGACT)

CPIC:

101938216(GGACT)

TST:	117870826(GGACT)

EOB:	135895139(GGACT)

CABI:

116837317(GGACT)

MRV:	120384236(GGACT)

EMQ:	137145869(GGACT)

ACS:	100551726(ggact)

ASAO:

132771488(GGACT)

PVT:	110083268(GGACT)

SUND:

121926968(GGACT)

PBI:	103053596(GGACT)

PMUR:

107298623(GGACT)

CTIG:

120305619(GGACT)

TSR:	106542956(GGACT)

PGUT:

117665868(GGACT)

PCAE:

139316294(GGACT)

APRI:

131199246(GGACT)

PTEX:

113441403(GGACT)

NSS:	113412964(GGACT)

VKO:	123023146(GGACT)

PMUA:

114596522(GGACT)

PRAF:

128411906(GGACT)

ZVI:	118084717(GGACT)

HCG:	128349463(GGACT)

GJA:	107113732(GGACT)

STOW:

125430844(GGACT)

EMC:	129326101(GGACT)

XLA:	447124(ggact.L)

XTR:	100379707(ggact)

NPR:	108804742(GGACT)

RTEM:

120926334(GGACT)

ACAT:

141127703(GGACT)

PADS:

140330975(GGACT)

BBUF:

120993499(GGACT)

BGAR:

122932697(GGACT)

HSQ:	130355491(GGACT)

PCOB:

135021413(GGACT)

DRE:	100038780(ggact.3) 447805(ggact.2) 777609(ggact.1)

DAES:

130220631 130220653 130233317(ggact.1) 130233327 130233336

SRX:	107730389 107735476 107744959

SANH:

107653666 107677844

SGH:	107559790 107560795 107571426

CCAR:

109083620 109086039 109107849 122136018

CAUA:

113044597 113085440 113099753 113100556

CGIB:

127948841 127949551 127949554 128012164

PTET:

122341978 122341983(ggact.3)

LROH:

127162062 127162069 127174999 127175323

GRF:	141336674 141337347

OMC:	131547751 131549867 131549893(ggact.3)

PPRM:

120460534 120460535

RKG:

130090956

MAMB:

125272793 125272795

CIDE:

127509939 127509942

CERY:

137032217 137032220

MASI:

127443519 127444971

TROS:

130552656(ggact.3)

TDW:

130438657

MANU:

129445085

PDAB:

135735664

IPU:	100528289(ggact)

IFU:	128608700 128608701

PHYP:

113547066(ggact)

SMEO:

124380144

TFD:

113640983

TVC:

132850604

CGAR:

128523744

NGRA:

132891630

TRN:

134324254

AMEX:

103030343

CMAO:

118807282

EEE:	113590773(ggact)

CHAR:

105911705 105911790

SPIL:

134071610 134071612

ASAD:

121698373 121698374

TRU:	101074567(ggact)

TFS:

130522397

NCC:	104943767(ggact)

TBEN:

117498898

CGOB:

115018868(ggact)

GACU:

117559106

EMAC:

134860886

ELY:	117250134 117250189

EFO:	125885016 125885027

PLEP:

121962945 121963007 121965763

SLUC:

116044514

SVIT:

144512555

ECRA:

117939317

ESP:	116674191(ggact)

PFLV:

114551028(ggact)

PFLT:

120554447

GAT:

120816060

PPUG:

119221060

AFB:

129111602

CLUM:

117741365

PSWI:

130204700

CANA:

137794112

CVE:

137879156

AMIR:

142952638

MSAM:

119904184

SCHU:

122871778

EARM:

139306839

CUD:

121506084

SPUL:

138603662

LMIX:

132959488

HTC:

141785999

ALAT:

119015556

ASTR:

137591161

PKLU:

139223836

LCO:	104936515(ggact)

MZE:	101480356 105941377 106675826

ONL:	100705894 100708742 100709281 106096423

OAU:	116310277 116310279 116310280 116310284

OLA:	101169771(ggact)

OML:

112159990

CSAI:

133425008

XMA:	102235923 102236181

XCO:	114140934 114140935

XHE:	116715939 116715943 116716689

PRET:

103460836

PFOR:

103152109 103152110

PLAI:

106940778 106940779

PMEI:

106909829 106909830

GAF:	122827116 122827117

PPRL:

129353782 129353821

CVG:	107095373 107095376

CTUL:

119773084 119773085

GMU:

124861712

NFU:	107380850(ggact)

KMR:

108245004

ALIM:

106511416(ggact)

NWH:	119428704 119428705

LTU:

140310073

AOCE:

111587770

EJA:

138207063

BFRE:

138628664

LCF:

108894891

CSEM:

103389510(ggact)

POV:	109638894(ggact)

SSEN:

122765114

SSOE:

131446951

HHIP:

117778511

HSP:

118103498

PPLT:

128430805

SMAU:

118313826

SDU:	111236754(ggact)

SLAL:

111644439(ggact)

XGL:

120798124

HCQ:	109508711(ggact)

SSCV:

125988219

PEE:

133413844

PTAO:

133473226

BPEC:

110153322(ggact)

ENY:

140362582

MALB:

109971413(ggact)

BSPL:

114866581

SJO:

128354471

SSCO:

133976254

TTY:

137176892

GMH:	115547766(ggact)

SASA:

100196396(tina1) 106590875

STRU:

115183175 115186273

OTW:	112241050 121845033

OMY:	110515619 118948705

OGO:	124023314 124028615

OKI:	109885069 116370621

OKE:

127918368

OMM:

135543145

OCLA:

139372233 139372234 139414071

SALP:

112075708(ggact)

SNH:

120040945

SFON:

129840512

CCLU:

121561627 123486985

ELS:	105020073 105020075

OEP:

134007941

SFM:	108920414(ggact)

PKI:	111852783(ggact)

AANG:

118213970

AROT:

135241433

CCOG:

133116363

LOC:	102696144(ggact)

PSPA:

121320695

ARUT:

117406734

PSEX:

120523468

LCM:	102353283(GGACT)

CMK:	103174595(ggact.3)

RTP:

109930360

CPLA:

122550492

HOC:

132816659

SCAU:

119977584

LERI:

129697921

HAKA:

140716069

BFO:

118403370

BBEL:

109474264

SPU:	115922378 593809 762872

LPIC:

129256943 129268431 129268536 129268645 129271467

LVG:	121410484 121423467 121426228 121426236

AJJ:	139966902 139982827

APLC:

110977371

ARUN:

117288239

AAMU:

139937552

AFIL:

140151687 140151698 140152638 140152646 140152734 140152745

DMN:

108159650

DWI:

6638308

ALUD:

128866939

TDA:

119685348

AGA:

133393605

ACOZ:

120955131

AARA:

120901546

AMER:

121599111

ASTE:

118503443

AMAP:

126556353

AFUN:

125767549

AMOU:

128308620

AMRS:

128707971

ANIL:

128732006

AALI:

118465510

ADAR:

125953521

ACOS:

131261355

CBRI:

134828594

CNS:

116340049

BCOO:

119070938 119081313

LLL:

129794168

PPAP:

129800445

PBX:

123717512

CCRC:

123704207

HAW:

110379903

HZE:

124643526

TNL:

113504119

SLIU:

111350085

ATRA:

106131310

PGW:

126378521

LGLY:

125238716

CSTB:

134752878

CFUM:

141443187

DPA:

109542687

AME:

550955

ACER:

107998837

ALAB:

122714348

ADR:

102681639

AFLR:

100871129

BIM:

100740880

BBIF:

117216323

BVK:

117231583

BVAN:

117154688

BHUN:

126872733

BTER:

100651657

BAFF:

126922610

BPYO:

122574204

BPAS:

132911299

FVI:

122530629

CCAL:

108633035

OBB:

114880712

OLG:

117603319

MGEN:

117218826

NMEA:

116430287

CGIG:

122405446

SOC:

105196178

MPHA:

105841007

AEC:

105145796

TSEP:

108745956

PBAR:

105430166

VEM:

105567176

COBS:

139103107

TLN:

139816258

HST:

105184360

CFO:

105254835

PGC:

109857993

PFUC:

122526431

VPS:

122627176

VCRB:

124422110

NVI:

100122076

CSOL:

105361039

TPRE:

106660379

MDL:

103568148

CGLO:

123262627

CTYP:

141537064

DAM:

107044255

VCAN:

122418433

CCIN:

107274617

AROA:

105688387

API:

100167721

DNX:

107162881

AGS:

114122680

RMD:

113549971

ACOO:

126835179

NLU:

111059109

LDA:	142323166 142327804

HVI:

124369990

MQU:	128983291 128999588

PHU:	Phum_PHUM308890

ZNE:

110830099

IEL:

124168875

HAMR:

139697439

FCD:

110844644

TCF:	131877219 131879023

PVM:

113811465

PJA:

122256797

PCHN:

125047263

PMOO:

119593076

HAZT:

108677797

PPOI:

119095533 119096100

DSV:	119448802 119448804 119450372 119450461 119456431 119456903

DALB:

135915783 139057868

RSAN:

119383168 119394659

RMP:

119171784

GOE:	100902907 100907965 100908385

DPTE:

113795421

DFR:

124498548

CSCU:

111618656

ABRU:

129980729

SDM:

118195402

LPOL:

106460151 106460408

PMEO:

129592003

NAI:	NECAME_18590

LGI:	LOTGIDRAFT_124020

PVUL:

126822249

PCAN:

112557811 112557814

LSAX:

138947438

BARL:

143290528

BGT:

106071026

GAE:

121385471

HRF:

124135847

HRJ:

124262680

HASI:

137297630

HCRA:

139463980

CRG:	105325394 105330230 117684052 117684059

CANU:

128163542 128163543 128170738

CVN:	111105555 111105612 111110839 111112221 111124723

OED:

125651655

MYI:	110443068 110460811

PMAX:

117315658 117315675 117322408

AIRR:

138320969 138321639 138322513

YBA:	132548138 132548252 132556824

MCAF:

127729212

MMER:

123560330 123560331

DPOL:

127859341

MAEA:

128233458

LJP:

135464086

LAK:

106162528

HSY:

130621637

AQU:	105312139 105314759 105315664

» show all

Reference

1 [PMID:6107907]

Authors

Fink ML, Chung SI, Folk JE

Title

gamma-Glutamylamine cyclotransferase: specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds.

Journal

Proc Natl Acad Sci U S A 77:4564-8 (1980)
DOI:10.1073/pnas.77.8.4564

Reference

2 [PMID:20110353]

Authors

Oakley AJ, Coggan M, Board PG

Title

Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.

Journal

J Biol Chem 285:9642-8 (2010)
DOI:10.1074/jbc.M109.082099

Sequence

[hsa:87769]

Other DBs

ExplorEnz - The Enzyme Database:

4.3.2.8

IUBMB Enzyme Nomenclature:

4.3.2.8

ExPASy - ENZYME nomenclature database:

4.3.2.8

BRENDA, the Enzyme Database:

4.3.2.8

LinkDB

DBGET integrated database retrieval system