Entry
Name
gamma-glutamylamine cyclotransferase;
GGACT
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
BRITE hierarchy
Sysname
epsilon-(gamma-L-glutamyl)-L-lysine gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
Reaction(IUBMB)
epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline [RN:
R11862 ]
Reaction(KEGG)
Substrate
epsilon-(gamma-L-glutamyl)-L-lysine [CPD:
C21730 ]
Product
Comment
The enzyme, found in vertebrates, has no activity toward alpha-(gamma-L-glutamyl)-L-amino acids (cf. EC
4.3.2.9 , gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
History
EC 4.3.2.8 created 2017
Reference
Authors
Fink ML, Chung SI, Folk JE
Title
gamma-Glutamylamine cyclotransferase: specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds.
Journal
Reference
Authors
Oakley AJ, Coggan M, Board PG
Title
Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.8
ExPASy - ENZYME nomenclature database: 4.3.2.8
BRENDA, the Enzyme Database: 4.3.2.8
LinkDB
All DBs