ENZYME: 4.4.1.41
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Entry
EC 4.4.1.41 Enzyme
Name
(2S)-3-sulfopropanediol sulfolyase;
DHPS sulfolyase;
hpsG (gene name)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2S)-2,3-dihydroxypropane-1-sulfonate sulfite-lyase
Reaction(IUBMB)
(2S)-2,3-dihydroxypropane-1-sulfonate = hydroxyacetone + sulfite [RN:
R12764
]
Reaction(KEGG)
R12764
Reaction
Substrate
(2S)-2,3-dihydroxypropane-1-sulfonate [CPD:
C22383
]
Product
hydroxyacetone [CPD:
C05235
];
sulfite [CPD:
C00094
]
Comment
The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster.
History
EC 4.4.1.41 created 2021
Orthology
K25264
(2S)-3-sulfopropanediol sulfolyase
Genes
DMS
:
E8L03_03165
DDN
:
DND132_2019
PNW
:
SYK_15720
PTHE
:
LF599_01200
DBA
:
Dbac_2145
Taxonomy
Reference
1 [PMID:
32571930
]
Authors
Liu J, Wei Y, Lin L, Teng L, Yin J, Lu Q, Chen J, Zheng Y, Li Y, Xu R, Zhai W, Liu Y, Liu Y, Cao P, Ang EL, Zhao H, Yuchi Z, Zhang Y.
Title
Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate.
Journal
Proc Natl Acad Sci U S A 117:15599-15608 (2020)
DOI:
10.1073/pnas.2003434117
Other DBs
ExplorEnz - The Enzyme Database:
4.4.1.41
IUBMB Enzyme Nomenclature:
4.4.1.41
ExPASy - ENZYME nomenclature database:
4.4.1.41
BRENDA, the Enzyme Database:
4.4.1.41
LinkDB
All DBs
DBGET
integrated database retrieval system