KEGG ENZYME: 5.1.1.22

ENZYME: 5.1.1.22

Entry

EC 5.1.1.22                 Enzyme

Name

4-hydroxyproline betaine 2-epimerase;
hpbD (gene name);
Hyp-B 2-epimerase;
(4R)-4-hydroxyproline betaine 2-epimerase

Class

Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives

Sysname

4-hydroxyproline betaine 2-epimerase

Reaction(IUBMB)

(1) trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine [RN:R11630];
(2) L-proline betaine = D-proline betaine [RN:R11631]

Reaction(KEGG)

R11630 R11631

Substrate

trans-4-hydroxy-L-proline betaine [CPD:C08269];
L-proline betaine [CPD:C10172]

Product

cis-4-hydroxy-D-proline betaine [CPD:C21513];
D-proline betaine [CPD:C21514]

Comment

The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyses racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position.

History

EC 5.1.1.22 created 2017

Orthology

K21617

4-hydroxyproline betaine 2-epimerase

Genes

PSIL:

PMA3_10220

BYI:	BYI23_B014710

BUE:	BRPE67_BCDS01700

MOP:	Mesop_5034

MAM:	Mesau_04624

MAMO:

A6B35_16510

MOH:	IHQ72_33425

AAK:	AA2016_6172

PHT:	BLM14_26775

SFH:	SFHH103_04926

SAME:

SAMCFNEI73_Ch0615

EMX:	FKV68_29025

NGG:	RG540_PA12520

SSUM:

Q9314_23860

LAP:	ACP90_26460

LABR:

CHH27_13985

LABT:

FIU93_04230(hpbD1)

LAGG:

B0E33_10510

RUT:	FIU92_12385(hpbD4)

RCON:

K3740_09955

LEJ:	ETW24_21190

RSP:

RSP_4007

PDE:

Pden_1187

PYE:	A6J80_02080

PPAN:

ESD82_09180

PVER:

E3U25_13270

PFEO:

E3U26_02065

PTP:	RCA23_c27060

DON:	BSK21_09365

AMYL:

QBD29_17240

MDX:	BTO20_21615 BTO20_21695

ROP:

ROP_23190

RKO:	JWS14_15355

SGRF:

SGFS_097590

ARQ:	BWQ92_13295

GOB:

Gobs_2848

PMAD:

BAY61_13345

ACTY:

OG774_04160

» show all

Reference

1 [PMID:24056934]

Authors

Zhao S, Kumar R, Sakai A, Vetting MW, Wood BM, Brown S, Bonanno JB, Hillerich BS, Seidel RD, Babbitt PC, Almo SC, Sweedler JV, Gerlt JA, Cronan JE, Jacobson MP

Title

Discovery of new enzymes and metabolic pathways by using structure and genome context.

Journal

Nature 502:698-702 (2013)
DOI:10.1038/nature12576

Reference

2 [PMID:24520058]

Authors

Kumar R, Zhao S, Vetting MW, Wood BM, Sakai A, Cho K, Solbiati J, Almo SC, Sweedler JV, Jacobson MP, Gerlt JA, Cronan JE

Title

Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.

Journal

MBio 5:e00933-13 (2014)
DOI:10.1128/mBio.00933-13