Entry
Name
L-dopachrome isomerase;
dopachrome tautomerase;
tyrosinase-related protein 2;
TRP-1;
TRP2;
TRP-2;
tyrosinase-related protein-2;
dopachrome Delta7,Delta2-isomerase;
dopachrome Delta-isomerase;
dopachrome conversion factor;
dopachrome isomerase;
dopachrome oxidoreductase;
dopachrome-rearranging enzyme;
DCF;
DCT;
dopachrome keto-enol isomerase;
L-dopachrome-methyl ester tautomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
L-dopachrome keto-enol isomerase
Reaction(IUBMB)
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate [RN:
R03673 ]
Reaction(KEGG)
Substrate
Product
5,6-dihydroxyindole-2-carboxylate [CPD:
C04185 ]
Comment
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC
4.1.1.84 , D-dopachrome decarboxylase).
History
EC 5.3.3.12 created 1992, modified 1999, modified 2005
Pathway
Orthology
Genes
PTEH : 111546588 113219501
SANH : 107662564 107666652
SGH : 107558385(dct) 107567421
CCAR : 109052004 109082707
MASI : 127447455 127448260
SASA : 100136917(dct) 100137092 106582441 106586271
STRU : 115155512 115160816 115160817
OTW : 112224185 112234462 112237246
OMY : 110501902 110520164 110520165
OGO : 124030708 124042904 124043915
ONE : 115109693 115109696 115131330
OKI : 109871377 109902627 109904283
SNH : 120057890 120057891 120063703
CCLU : 121536738 121554972
BFO : 118407975 118431962 118431963
BBEL : 109486120 109486121
SCLV : 120335869 120345801 120345802
DME : Dmel_CG18550(yellow-f) Dmel_CG8063
DSI : Dsimw501_GD20528(Dsim_GD20528) Dsimw501_GD20529(Dsim_GD20529)
DYA : Dyak_GE24474 Dyak_GE24475
ACOZ : 120948805 120953921 120953922 120953924
AARA : 120893185 120893186 120893187 120908778
AMER : 121588834 121588835 121588836 121590542
ASTE : 118502828 118505408 118505410 118505411
AFUN : 125761605 125766012 125766014 125766015
AMOU : 128296692 128298013 128299443 128299603
AAG : 5563570 5563593 5563621
AALB : 109412583 109412586 109412587 109433602 109433623 115259651
CQU : CpipJ_CPIJ002393 CpipJ_CPIJ002394 CpipJ_CPIJ002395
BCOO : 119066578 119067886 119067888 119072305 119083251 119084422 119085262
APLN : 108741681 108741682
BMOR : 101737203(yellow-11) 101737351 101737492 101738044 101738170 101738305 101738564 101738837 101740731 101741665 101741808 101741957 105841421 693000(Y-fa) 693002(Y-fb) 693004(Y-f2) 693006
BMAN : 114240104 114240105 114240199 114240221 114240222 114243745 114243750 114245737 114245738 114245740 114245769 114245811 114245812 114245834 114251500 114251509 114252251 114252906
MSEX : 115451342 115452856
DPL : KGM_215143A KGM_215143B
BANY : 112051002 112051004
MCIX : 123662436 123666168
PMAC : 106713422 106713423
PPOT : 106103071 106103072
PRAP : 110997292 110997307 123690450 123690452
PNAP : 125061311 125061314
CCRC : 123704604 123704818
LSIN : 126973707 126978166
SLIU : 111359817 111359823
CCRN : 123292058 123293772
» show all
Taxonomy
Reference
Authors
Solano F, Jimenez-Cervantes C, Martinez-Liarte JH, Garcia-Borron JC, Jara JR, Lozano JA.
Title
Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase.
Journal
Sequence
Reference
Authors
Pawelek JM.
Title
Dopachrome conversion factor functions as an isomerase.
Journal
Reference
Authors
Pennock JL, Behnke JM, Bickle QD, Devaney E, Grencis RK, Isaac RE, Joshua GW, Selkirk ME, Zhang Y, Meyer DJ
Title
Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.12
ExPASy - ENZYME nomenclature database: 5.3.3.12
LinkDB
All DBs