| Entry |
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| Name |
thiazole tautomerase;
tenI (gene name)
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
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| Sysname |
2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase
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| Reaction(IUBMB) |
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate = 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate [RN: R09977]
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| Reaction(KEGG) |
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| Substrate |
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate [CPD: C20246]
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| Product |
2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate [CPD: C20247]
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| Comment |
The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate.
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| History |
EC 5.3.99.10 created 2012
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| Pathway |
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| Orthology |
| K10810 | thiazole tautomerase (transcriptional regulator TenI) |
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| Genes |
| BAZ: | BAMTA208_11770(tenI) |
| BSON: | S101395_03589(tenI) |
| BTHI: | BTK_04255 BTK_04305 |
| BFD: | NCTC4823_00320(tenI) |
| CSPG: | LS684_11160(tenI) LS684_22820 |
| BLEN: | NCTC4824_01712(tenI) |
| ACHP: | QR721_10255 QR721_12705 |
| PARG: | PspKH34_31160(thiE_2) |
| SDP: | NCTC12225_02300(tenI) |
| PPQ: | PPSQR21_027030(thiE) |
| PABS: | JIR001_21600(thiE_2) |
| CPAE: | CPAST_c33340(thiE2) |
| CACE: | CACET_c37710(thiE2) |
| MEAR: | Mpt1_c00770(thiE1) Mpt1_c03060(thiE2) |
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| Reference |
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| Authors |
Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP |
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| Title |
A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 5.3.99.10 |
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| LinkDB |
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